Stroke is the second leading cause of death and a major contributor to disability worldwide.
The prevalence of stroke is highest in developing countries, with ischemic stroke being the …

The vast majority of cerebral stroke cases are caused by transient or permanent occlusion of
a cerebral blood vessel (“ischemic stroke”) eventually leading to brain infarction. The final …

The blood-brain barrier (BBB) protects the central nervous system (CNS) from harmful blood-
borne factors. Although BBB dysfunction is a hallmark of several neurological disorders …

Ischemic stroke is the leading cause of human disability and mortality in the world. The main
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …

This review outlines the most frequently used rodent stroke models and discusses their
strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is …

Early diagnosis and treatment of acute ischemic stroke poses a significant challenge due to
its suddenness and short therapeutic time window. Human endogenous cells derived …

Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which
results in damage to neuronal networks and the impairment of sensation, movement or …

Monocyte-derived and tissue-resident macrophages are ontogenetically distinct
components of the innate immune system. Assessment of their respective functions in …

Studies of stroke have identified local reorganization in perilesional tissue. However,
because the brain is highly networked, strokes also broadly alter the brain's global network …

The cerebral vascular system services the constant demand for energy during neuronal
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …