Chloride transport through supramolecular barrel-rosette ion channels: lipophilic control and apoptosis-inducing activity

T Saha, A Gautam, A Mukherjee, M Lahiri… - Journal of the …, 2016 - ACS Publications
Despite the great interest in artificial ion channel design, only a small number of channel-
forming molecules are currently available for addressing challenging problems, particularly …

A rigid-axle-based molecular rotaxane channel facilitates K+/Cl− co-transport across a lipid membrane

S Pang, X Sun, Z Yan, C Wang, K Ye, S Ma… - Chemical …, 2023 - pubs.rsc.org
Inspired by the design criteria of heteroditopic receptors for ion-pair binding, we herein
describe a new strategy to construct a rotaxane transporter (RR [2]) for K+/Cl− co-transport …

Molecular rotaxane shuttle-relay accelerates K+/Cl symport across a lipid membrane

K Ye, Z Zhang, Z Yan, S Pang, H Yang, X Sun… - Science China …, 2023 - Springer
Synthetic molecules that can mediate the coupled transport of Cl− with K+ and/or Na+
across the lipid bilayers have aroused great interest due to their potential as a novel …

Apoptosis-inducing activity of a fluorescent barrel-rosette M+/Cl− channel

JA Malla, RM Umesh, A Vijay, A Mukherjee… - Chemical …, 2020 - pubs.rsc.org
Synthetic transmembrane ion transport systems are emerging as new tools for anticancer
therapy. Here, a series of 2-hydroxy-N1, N3-diarylisophthalamide-based fluorescent ion …

Diphenylethylenediamine-based potent anionophores: transmembrane chloride ion transport and apoptosis inducing activities

N Akhtar, A Saha, V Kumar, N Pradhan… - … applied materials & …, 2018 - ACS Publications
Synthetic anion transporters have been recognized as one of the potential therapeutic
agents for the treatment of diseases including cystic fibrosis, myotonia, and epilepsy that …

Acylhydrazone-based reversibly photoswitchable ion pair transporter with OFF–ON cotransport activity

S Chattopadhayay, P Wanjari, P Talukdar - Chemical Science, 2024 - pubs.rsc.org
The cellular membrane transport of physiologically important cations and anions is
omnipresent and regulates different physiological functions. Whereas a notable number of …

Supramolecular Barrel‐Rosette Ion Channel Based on 3, 5‐Diaminobenzoic Acid for Cation‐Anion Symport

S Chattopadhayay, A Ghosh… - Angewandte …, 2023 - Wiley Online Library
The structural tropology and functions of natural cation‐anion symporting channels have
been continuously investigated due to their crucial role in regulating various physiological …

Ligand Induced CuII Transport Restricts Cancer and Mycobacterial Growth: Towards a Plug‐and‐Select Ion Channel Scaffold

P Saha, P Kumari Agarwala, R Dadhich… - …, 2021 - Wiley Online Library
Synthetic channels with high ion selectivity are attractive drug targets for diseases involving
ion dysregulation. Achieving selective transport of divalent ions is highly challenging due …

A minimalistic tetrapeptide amphiphile scaffold for transmembrane pores with a preference for sodium

D Basak, S Sridhar, AK Bera, N Madhavan - Bioorganic & Medicinal …, 2017 - Elsevier
Synthetic channels or pores that are easy to synthesize, stable and cation-selective are
extremely attractive for the development of therapeutics and materials. Herein, we report a …

Basic Design Elements for Tunable Cation Transport Using Picolinic‐Acid‐Incorporated Tetrapeptides

D Basak, P Saha, N Madhavan - ChemistrySelect, 2018 - Wiley Online Library
Selective transport of cations across cell membranes is essential for various biological
functions in the body. Synthetic pores that mimic the selectivity of natural ion channels are …