Many adverse reactions to therapeutic drugs appear to be allergic in nature, and are thought
to be triggered by patient-specific Immunoglobulin E (IgE) antibodies that recognize the drug …

Pharmacokinetic/pharmacodynamic (PK/PD) analysis has proved to be very useful to
establish rational dosage regimens of antimicrobial agents in human and veterinary …

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government Here's how you know NIH NLM Logo Access keys NCBI Homepage MyNCBI …

The purpose of this review was to assess the advancement of applications for
physiologically based pharmacokinetic (PBPK) modeling in various therapeutic areas. We …

The older population consisting of persons aged 65 years or older is the fastest-growing
population group and also the major consumer of pharmaceutical products. Due to the …

Meloxicam, a non-steroidal anti-inflammatory drug, is used for the treatment of rheumatoid
arthritis and osteoarthritis. Cytochrome P450 (CYP) 2C9 and CYP3A4 are major and minor …

Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic
(PBPK) tools represents a promising method to describe and predict the in vivo performance …

Aims This study aims to develop and verify a physiologically based pharmacokinetic (PBPK)
population model for the Chinese geriatric population in Simcyp. Methods Firstly …

The application of statistical and artificial intelligence (AI) tools in building energy prediction
(BEP) is considered one of the most effective advances toward improving energy efficiency …

Aim The study was aimed to understand the underlying causes for the differences in
propranolol pharmacokinetics (PK) between healthy and cirrhosis populations by using a …