Incomplete excision of cervical precancer as a predictor of treatment failure: a systematic review and meta-analysis

M Arbyn, CWE Redman, F Verdoodt, M Kyrgiou… - The Lancet …, 2017 - thelancet.com
Background Incomplete excision of cervical precancer is associated with therapeutic failure
and is therefore considered as a quality indicator of clinical practice. Conversely, the risk of …

Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis

J Koshiol, L Lindsay, JM Pimenta… - American journal of …, 2008 - academic.oup.com
Detection of persistent cervical carcinogenic human papillomavirus (HPV) DNA is used as a
marker for cervical cancer risk in clinical trials. The authors performed a systematic review …

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical …

CL Trimble, MP Morrow, KA Kraynyak, X Shen… - The Lancet, 2015 - thelancet.com
Background Despite preventive vaccines for oncogenic human papillomaviruses (HPVs),
cervical intraepithelial neoplasia (CIN) is common, and current treatments are ablative and …

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression

C He, D Mao, G Hua, X Lv, X Chen… - EMBO molecular …, 2015 - embopress.org
The Hippo signaling pathway controls organ size and tumorigenesis through a kinase
cascade that inactivates Yes‐associated protein (YAP). Here, we show that YAP plays a …

[图书][B] Screening: evidence and practice

AE Raffle, A Mackie, JAM Gray - 2019 - books.google.com
Screening programmes involve the systematic offer of testing for populations or groups of
apparently healthy people to identify individuals who may be at future risk of a particular …

Persistence and load of high‐risk HPV are predictors for development of high‐grade cervical lesions: a longitudinal French cohort study

V Dalstein, D Riethmuller, JL Prétet… - … journal of cancer, 2003 - Wiley Online Library
Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small
proportion of infected women will develop high‐grade cervical intraepithelial neoplasia or …

Projected clinical benefits and cost-effectiveness of a human papillomavirus 16/18 vaccine

SJ Goldie, M Kohli, D Grima… - Journal of the …, 2004 - academic.oup.com
Background: Human papillomavirus (HPV) vaccine may be commercially available in a few
years. We explored the clinical benefits and cost-effectiveness of introducing an HPV16/18 …

2006 consensus guidelines for the management of women with abnormal cervical cancer screening tests

TC Wright Jr, LS Massad, CJ Dunton, M Spitzer… - American journal of …, 2007 - Elsevier
A group of 146 experts representing 29 organizations and professional societies met
September 18-19, 2006, in Bethesda, MD, to develop revised evidence-based, consensus …

Human papillomavirus infection and time to progression and regression of cervical intraepithelial neoplasia

NF Schlecht, RW Platt, E Duarte-Franco… - Journal of the …, 2003 - academic.oup.com
Background: Little is known about the duration of precancerous cervical lesions in relation to
human papillomavirus (HPV) infection. We estimated rates of progression and regression …

Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions

L Maldonado, JE Teague, MP Morrow… - Science translational …, 2014 - science.org
About 25% of high-grade cervical intraepithelial neoplasias (CIN2/3) caused by human
papillomavirus serotype 16 (HPV16) undergo complete spontaneous regression. However …