Protein misfolding and amyloid nucleation through liquid–liquid phase separation

S Mukherjee, M Poudyal, K Dave, P Kadu… - Chemical Society …, 2024 - pubs.rsc.org
Liquid–liquid phase separation (LLPS) is an emerging phenomenon in cell physiology and
diseases. The weak multivalent interaction prerequisite for LLPS is believed to be facilitated …

Protein structure–function continuum model: Emerging nexuses between specificity, evolution, and structure

MN Gupta, VN Uversky - Protein Science, 2024 - Wiley Online Library
The rationale for replacing the old binary of structure–function with the trinity of structure,
disorder, and function has gained considerable ground in recent years. A continuum model …

Ultrathin aerogel-structured micro/nanofiber metafabric via dual air-gelation synthesis for self-sustainable heating

Y Tian, Y Chen, S Wang, X Wang, J Yu… - Nature …, 2024 - nature.com
Incorporating passive heating structures into personal thermal management technologies
could effectively mitigate the escalating energy crisis. However, current passive heating …

Machine learning predictor PSPire screens for phase-separating proteins lacking intrinsically disordered regions

S Hou, J Hu, Z Yu, D Li, C Liu, Y Zhang - Nature Communications, 2024 - nature.com
The burgeoning comprehension of protein phase separation (PS) has ushered in a wealth of
bioinformatics tools for the prediction of phase-separating proteins (PSPs). These tools often …

Biomolecular Condensation of Trypsin Prevents Autolysis and Promotes Ca2+-Mediated Activation of Esterase Activity

CK Patel, TK Mukherjee - Biomacromolecules, 2024 - ACS Publications
The presence of Ca2+ ions is known to facilitate the activity of trypsin-like serine proteases
via structural stabilization against thermal denaturation and autolysis. Herein, we report a …

Energy‐Harvesting Carbon Aerogel Nanofiber Metafabric for High‐Efficiency Thermoregulation

Y Tian, Y Chen, S Wang, X Wang, J Yu… - Advanced Functional …, 2024 - Wiley Online Library
Maintaining body temperature within safe and comfortable range is crucial; however,
thermoregulatory materials face challenges in variable environments and extreme …

A Hydroxyquinoline Polymer with Excellent Amyloidosis Inhibition and Protein Delivery Ability to Combat Amyloid-β-Mediated Neurotoxicity

L Chen, Y Hu, Y Cheng, H Wang - Nano Letters, 2024 - ACS Publications
The accumulation of abnormal protein deposits known as amyloid-β (Aβ) plaques
contributes to the development and progression of Alzheimer's disease. Aggregated Aβ …

Spatiotemporal formation of a single liquid-like condensate and amyloid fibrils of α-synuclein by optical trapping at solution surface

K Yuzu, CY Lin, PW Yi, CH Huang, H Masuhara… - Proceedings of the …, 2024 - pnas.org
Liquid-like protein condensates have recently attracted much attention due to their critical
roles in biological phenomena. They typically show high fluidity and reversibility for …

Multiscale simulations reveal the driving forces of p53C phase separation accelerated by oncogenic mutations

Y Yu, Q Liu, J Zeng, Y Tan, Y Tang, G Wei - Chemical Science, 2024 - pubs.rsc.org
Liquid–Liquid phase separation (LLPS) of p53 to form liquid condensates has been
implicated in cellular functions and dysfunctions. The p53 condensates may serve as …

Recombinant silk protein condensates show widely different properties depending on sample background

J Tersteegen, I Tunn, M Sand, T Välisalmi… - Journal of Materials …, 2024 - pubs.rsc.org
There is an increasing understanding that condensation is a crucial intermediate step in the
assembly of biological materials and for a multitude of cellular processes. To apply and to …