Early diagnostic is one of the most important steps in cancer therapy which helps to design
and choose a better therapeutic approach. The finding of biomarkers in various levels …

I mmunodeficiency, c entromeric instability, and f acial anomalies (ICF) syndrome is a rare
autosomal recessive disorder characterized by DNA hypomethylation and antibody …

Abstract Purpose: PI3K inhibitors (PI3Ki) are approved for relapsed chronic lymphocytic
leukemia (CLL). Although patients may show an initial response to these therapies …

Simple Summary Despite continued efforts, the current status of knowledge in CLL
molecular pathobiology, diagnosis, prognosis and treatment remains elusive and imprecise …

Indolent non-Hodgkin's lymphoma (iNHL) describes a group of B-cell lymphomas with a
long median survival and a relapsing–remitting clinical course. Although existing treatments …

Simple Summary The PI3K/AKT pathway is involved in cell survival and proliferation.
Molecular aberrations and/or hyperactivation of the PI3K-PTEN-AKT axis are frequent in …

Clonal expansion of B cell chronic lymphocytic leukemia (B-CLL) occurs within lymphoid
tissue pseudofollicles. IL-15, a stromal cell–associated cytokine found within spleens and …

Lymphocyte migration to and sequestration in specific microenvironments plays a crucial
role in their differentiation and survival. Lymphocyte trafficking and homing are tightly …

The advent of novel targeted therapies, including B-cell receptor (BCR) pathway and B-cell
lymphoma 2 (BCL2) inhibitors, has substantially changed the treatment paradigm for chronic …

Introduction Outcomes in chronic lymphocytic leukemia (CLL) have been dramatically
improved with the addition of anti-CD20 antibodies to chemotherapy, defining a new …