The formation and maintenance of neural circuits in the mammal central nervous system
(CNS) require the coordinated expression of genes not just at the transcriptional level, but at …

The transport of messenger RNAs (mRNAs) in neurons serves many purposes. During
development, trafficking of mRNAs to both axonal and dendritic growth cones regulates …

Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

Caprin-1 is a ubiquitously expressed, well-conserved cytoplasmic phosphoprotein that is
needed for normal progression through the G1-S phase of the cell cycle and occurs in …

In brain, mRNAs are transported from the cell body to the processes, allowing for local
protein translation at sites distant from the nucleus. Using subcellular fractionation, we …

Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a
polyglutamine repeat within the HD gene product, huntingtin. Huntingtin, a large (347 kDa) …

Fused in sarcoma (FUS) is an RNA-binding protein involved in pathogenesis of several
neurodegenerative diseases. Aggregation of mislocalized FUS into non-amyloid inclusions …

SOX2 is a key gene implicated in maintaining the stemness of embryonic and adult stem
cells that appears to re‐activate in several human cancers including glioblastoma …

Regulated cell metabolism involves acute and chronic regulation of gene expression by
various nutritional and endocrine stimuli. To respond effectively to endogenous and …

Cytoplasmic activation/proliferation-associated protein-1 (Caprin-1) is a cytoplasmic
phosphoprotein that is the prototype of a novel family of highly conserved proteins. Its levels …