Reactive oxygen species (ROS) are produced by living organisms as a result of normal
cellular metabolism and environmental factors, such as air pollutants or cigarette smoke …

BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

▪ Abstract This review describes the three mammalian glutathione transferase (GST)
families, namely cytosolic, mitochondrial, and microsomal GST, the latter now designated …

BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

Glutathione transferases (GSTs) are a diverse family of enzymes found ubiquitously in
aerobic organisms. They play a central role in the detoxification of both endogenous and …

In the last decade the tumultuous development of “omics” greatly improved our ability to
understand protein structure, function and evolution, and to define their roles and networks …

The water flea Daphnia magna is a small planktonic cladoceran. D. magna has been used
as a model species for ecotoxicology, as it is sensitive to environmental stressors and …

Molecular dynamics simulations have become a popular and powerful technique to study
lipids and membrane proteins. We present some general questions and issues that should …

Bacterial glutathione transferases (GSTs) are part of a superfamily of enzymes that play a
key role in cellular detoxification. GSTs are widely distributed in prokaryotes and are …

Expression of recombinant proteins as fusions to the eukaryotic protein ubiquitin has been
found to significantly increase the yield of unstable or poorly expressed proteins. The benefit …