Glioma is the most frequent and aggressive type of brain neoplasm, being anaplastic
astrocytoma (AA) and glioblastoma multiforme (GBM), its most malignant forms. The survival …

Stress as a modern civilization factor significantly affects our lives. While acute stress might
have a positive effect on the organism, chronic stress is usually detrimental and might lead …

Background: The use of β-blockers for the management of hypertension has been recently
associated with significant clinical benefits in cancer patients. Herein, we investigated …

Glioblastoma multiforme is the most malignant and aggressive type of brain tumor, with a
mean life expectancy of less than 15 months. This is due in part to the high resistance to …

Drug repurposing or repositioning has been well-known to refer to the therapeutic
applications of a drug for another indication other than it was originally approved for …

Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

Aim The aim of this study was to investigate the potential cardioprotective and anti-cancer
effects of carvedilol (CAR) either free or as loaded nano-formulated with or without …

Glioblastoma is associated with a poor prognosis. Even though survival statistics are well-
described at the population level, it remains challenging to predict the prognosis of an …

An increasing resistance of mammalian tumor cells to chemotherapy along with the severe
side effects of commonly used cytostatics has raised the urgency in the search for new anti …

Glioblastoma multiforme is the most common, aggressive and lethal type of brain tumor. It is
a stage IV cancer disease with a poor prognosis, as the current therapeutic options (surgery …