Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

The presence of symptom clusters, regional differences in disease expression and
similarities with, for example, Crohn's disease suggest multiple pathological pathways are …

Systemic autoinflammatory diseases are driven by abnormal activation of innate immunity.
Herein we describe a new disease caused by high-penetrance heterozygous germline …

Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by homozygous
or compound heterozygous gain-of-function mutations in MEFV, which encodes pyrin, an …

Behçet's disease is a chronic multisystem inflammatory disorder characterized mainly by
recurrent oral ulcers, ocular involvement, genital ulcers, and skin lesions, presenting with …

Inflammasomes are intracellular multiprotein signaling complexes, mainly present in
myeloid cells. They commonly assemble around a cytoplasmic receptor of the nucleotide …

Behçet's disease is a systemic vasculitis frequently associated with intraocular inflammation.
Recent findings identified independent clinical clusters in Behçet's disease, each involving …

Abstract We analyzed 1,900 Turkish Behçet's disease cases and 1,779 controls genotyped
with the Immunochip. The most significantly associated SNP was rs1050502, a tag SNP for …

BD is a systemic inflammatory disease with a variable vasculitis. Paediatric onset is very rare
and carries a strong genetic component. Oral ulcers and fever of unknown origin are …

Behçet's disease (BD) is an inflammatory disorder of unknown aetiology characterised by
recurrent attacks affecting the mucocutaneous tissues, eyes, joints, blood vessels, brain and …