It is textbook knowledge that carboxamides benefit from increased stabilisation of the
electrophilic carbonyl carbon when compared to other carbonyl and carboxyl derivatives …

The nucleophilic addition of carbon nucleophiles to amides has traditionally been a difficult
task, both due to reactivity and selectivity problems. When successful, these processes …

Covering: July 2001 to December 2012 This review covers pyrrolizidine alkaloids isolated
from natural sources. Topics include: aspects of structure, isolation, and biological …

Full details of the direct and general method for the reductive alkylation of tertiary lactams
and amides to give tertiary sec-alkylamines are presented. This one-pot method consists of …

Terminal alkene substrates can be converted to methyl ketone products via a palladium‐
catalyzed process known as the Wacker oxidation. This process has found widespread …

A formal enantioselective total synthesis of the potent immunosuppressant FR901483 (1)
has been accomplished. Our approach features the use of chiron 6 as the starting material …

Pyrrolizidine or azabicyclo [3.3. 0]-octane (Figure 1) and its derivatives are a very common
azabicycle motif within natural products (pyrrolizidine alkaloids, PAs) possessing a bridge …

This is the first report on an intramolecular C–N bond formation of an amide-tethered
benzylic/allylic system using DDQ under neutral conditions which has been successfully …

Carbon-carbon bond formation and functional group transformation are two cornerstones of
organic synthesis. Generally, most of the established methods involve the transformation of …

This review summarizes recently established methodologies developed for the
enantioselective and diastereoselective synthesis of chiral 1, 3-oxazines. These compounds …