Exploring multifunctional antioxidants as potential agents for management of neurological disorders

RK Sindhu, P Kaur, P Kaur, H Singh… - … Science and Pollution …, 2022 - Springer
Free radical or oxidative stress may be a fundamental mechanism underlying several
human neurologic diseases. Therapy using free radical scavengers (antioxidants) has the …

Antioxidants as a preventive treatment for epileptic process: a review of the current status

B Martinc, I Grabnar, T Vovk - Current neuropharmacology, 2014 - ingentaconnect.com
Epilepsy is known as one of the most frequent neurological diseases, characterized by an
enduring predisposition to generate epileptic seizures. Oxidative stress is believed to …

Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation

PF Hsieh, CW Hou, PW Yao, SP Wu, YF Peng… - Journal of …, 2011 - Springer
Background Kainic acid (KA)-induced status epilepticus (SE) was involved with release of
free radicals. Sesamin is a well-known antioxidant from sesame seeds and it scavenges free …

The effects of ascorbic acid on penicillin‐induced epileptiform activity in rats

M Ayyildiz, S Coskun, M Yildirim, E Agar - Epilepsia, 2007 - Wiley Online Library
Purpose: Epileptic seizure results from excessive discharge in a population of
hyperexcitable neurons. A number of studies help to document the effects of active oxygen …

Functional nutrients for epilepsy

JE Kim, KO Cho - Nutrients, 2019 - mdpi.com
Epilepsy is a common neurological disorder of which seizures are a core symptom.
Approximately one third of epileptic patients are resistant to antiepileptic drugs and therefore …

The effect of Vitamin E on learning and memory deficits in intrahippocampal kainate-induced temporal lobe epilepsy in rats

Z Kiasalari, M Khalili, S Shafiee… - Indian journal of …, 2016 - journals.lww.com
Objective: Since temporal lobe epilepsy (TLE) is associated with learning and memory
impairment, we investigated the beneficial effect of Vitamin E on the impaired learning and …

Targeting oxidative stress component in the therapeutics of epilepsy

F Azam, M VV Prasad… - Current Topics in …, 2012 - ingentaconnect.com
The role of free radical-mediated reactions in human neuropathology continues to attract
significant interest. Oxidative injury produced by free radicals may play a role in the initiation …

[HTML][HTML] Inhibitory action of antioxidants (ascorbic acid or α-tocopherol) on seizures and brain damage induced by pilocarpine in rats

AR Tomé, PMP Ferreira, RM Freitas - Arquivos de Neuro-Psiquiatria, 2010 - SciELO Brasil
Temporal lobe epilepsy is the most common form of epilepsy in humans. Oxidative stress is
a mechanism of cell death induced by seizures. Antioxidant compounds have …

Effects of intracortical microinjection of vitamin B12 on penicillin-induced epileptiform activity in rats

A Erfanparast, E Tamaddonfard - Acta Neurobiologiae Experimentalis, 2015 - ane.pl
There are increasing studies indicating neuroprotective effects for vitamin B12. In the
present study, the effect of intracortical microinjection of vitamin B12 was investigated on …

The effect of fluoxetine on penicillin-induced epileptiform activity

H Aygun - Epilepsy & Behavior, 2019 - Elsevier
Aim Depression is the most frequent psychiatric comorbidity in patients with epilepsy.
Fluoxetine is the most widely used selective serotonin reuptake inhibitor (SSRI) in …