Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …
Cellular bioenergetics as a target for obesity therapy
Obesity develops when energy intake exceeds energy expenditure. Although most current
obesity therapies are focused on reducing calorific intake, recent data suggest that …
obesity therapies are focused on reducing calorific intake, recent data suggest that …
PPARs-orchestrated metabolic homeostasis in the adipose tissue
C Sun, S Mao, S Chen, W Zhang, C Liu - International journal of …, 2021 - mdpi.com
It has been more than three decades since peroxisome proliferator-activated receptors
(PPARs) were first discovered. Many investigations have revealed the central regulators of …
(PPARs) were first discovered. Many investigations have revealed the central regulators of …
[HTML][HTML] Metabolic adaptations through the PGC-1α and SIRT1 pathways
Energy homeostasis in mammals is achieved through tight regulation of tissue-specific
metabolic pathways that become dysregulated in metabolic diseases including diabetes and …
metabolic pathways that become dysregulated in metabolic diseases including diabetes and …
Brown adipose tissue and its role in insulin and glucose homeostasis
K Maliszewska, A Kretowski - International journal of molecular sciences, 2021 - mdpi.com
The increased worldwide prevalence of obesity, insulin resistance, and their related
metabolic complications have prompted the scientific world to search for new possibilities to …
metabolic complications have prompted the scientific world to search for new possibilities to …
Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss
BØ Christoffersen, G Sanchez‐Delgado, LM John… - …, 2022 - Wiley Online Library
New appetite‐regulating antiobesity treatments such as semaglutide and agents under
investigation such as tirzepatide show promise in achieving weight loss of 15% or more …
investigation such as tirzepatide show promise in achieving weight loss of 15% or more …
Huntington's disease and mitochondria
M Jodeiri Farshbaf, K Ghaedi - Neurotoxicity research, 2017 - Springer
Huntington's disease (HD) as an inherited neurodegenerative disorder leads to neuronal
loss in striatum. Progressive motor dysfunction, cognitive decline, and psychiatric …
loss in striatum. Progressive motor dysfunction, cognitive decline, and psychiatric …
[HTML][HTML] Lipid droplet remodeling and interaction with mitochondria in mouse brown adipose tissue during cold treatment
Brown adipose tissue (BAT) maintains animal body temperature by non-shivering
thermogenesis, which is through uncoupling protein 1 (UCP1) that uncouples oxidative …
thermogenesis, which is through uncoupling protein 1 (UCP1) that uncouples oxidative …
Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes [S]
Peroxisome proliferator-activated receptor-α (PPARα) is a dietary lipid sensor, whose
activation results in hypolipidemic effects. In this study, we investigated whether PPARα …
activation results in hypolipidemic effects. In this study, we investigated whether PPARα …
BAT: a new target for human obesity?
Two types of adipose tissue can be distinguished histologically and functionally: white
(WAT) and brown adipose tissue (BAT). Whereas BAT is specialized in the production of …
(WAT) and brown adipose tissue (BAT). Whereas BAT is specialized in the production of …