Gut microbiota influence immunotherapy responses: mechanisms and therapeutic strategies

Y Lu, X Yuan, M Wang, Z He, H Li, J Wang… - Journal of hematology & …, 2022 - Springer
The gut microbiota have long been recognized to play a key role in human health and
disease. Currently, several lines of evidence from preclinical to clinical research have …

Immune-related toxicities of checkpoint inhibitors: mechanisms and mitigation strategies

RJ Sullivan, JS Weber - Nature reviews Drug discovery, 2022 - nature.com
The immune-related adverse events associated with treatment with immune checkpoint
inhibitors result in significant morbidity for patients as well as considerable cost to the health …

Clinically relevant prognostic and predictive markers for immune-checkpoint-inhibitor (ICI) therapy in non-small cell lung cancer (NSCLC)

WM Brueckl, JH Ficker, G Zeitler - BMC cancer, 2020 - Springer
Background Immune checkpoint inhibitors (ICI) either alone or in combination with
chemotherapy have expanded our choice of agents for the palliative treatment of non-small …

Immune-related adverse events and survival among patients with metastatic NSCLC treated with immune checkpoint inhibitors

S Cook, V Samuel, DE Meyers, I Stukalin… - JAMA Network …, 2024 - jamanetwork.com
Importance Immune-related adverse events (irAEs) secondary to immune checkpoint
inhibitor (ICI) therapy reportedly improve overall survival (OS) in patients with non–small cell …

Association between immune-related adverse event timing and treatment outcomes

D Hsiehchen, AR Naqash, M Espinoza… - …, 2022 - Taylor & Francis
The timing of immune-related adverse events (irAE) associated with immune checkpoint
inhibitors (ICI) is highly variable. Although the development of irAE has been associated with …

Gut microbiota-mediated immunomodulation in tumor

X Liu, Y Chen, S Zhang, L Dong - Journal of Experimental & Clinical …, 2021 - Springer
Tumor immunity consists of various types of cells, which serve an important role in antitumor
therapy. The gastrointestinal tract is colonized by trillions of microorganisms, which form the …

Immune-related adverse events (irAE) in cancer immune checkpoint inhibitors (ICI) and survival outcomes correlation: to rechallenge or not?

HJ Albandar, J Fuqua, JM Albandar, S Safi, SA Merrill… - Cancers, 2021 - mdpi.com
Simple Summary This study examined the real-world experience and occurrence of immune-
related adverse events (irAEs) under cancer checkpoint immunotherapy, and the …

[HTML][HTML] Effectiveness and safety of immunotherapy in NSCLC patients with ECOG PS score≥ 2–systematic review and meta-analysis

B Tomasik, M Bieńkowski, M Braun, S Popat… - Lung Cancer, 2021 - Elsevier
Abstract Background Immune checkpoint inhibitors (ICIs) are standard of care in advanced
non-small cell lung cancer (NSCLC), however their status in patients with poor performance …

Autoantibodies in patients with immune-related adverse events from checkpoint inhibitors: A systematic literature review

N Ghosh, KK Chan, B Jivanelli… - JCR: Journal of Clinical …, 2022 - journals.lww.com
Background Immune-related adverse events (irAEs) from immune checkpoint inhibitors
(ICIs) are sometimes associated with autoantibodies, but we do not know how frequently or …

Immune-related adverse events predict the efficacy of immune checkpoint inhibitors in lung cancer patients: a meta-analysis

D Wang, C Chen, Y Gu, W Lu, P Zhan, H Liu… - Frontiers in …, 2021 - frontiersin.org
Background Immune-related adverse events (irAEs) have been reported to be associated
with the efficacy of immunotherapy. Herein, we conducted a meta-analysis to demonstrate …