The manufacture of recombinant therapeutics is a fastest-developing section of therapeutic
pharmaceuticals and presently plays a significant role in disease management. Yeasts are …

Yeasts have been widely used for production of bread, beer and wine, as well as for
production of bioethanol, but they have also been designed as cell factories to produce …

Eukaryotic cells are used as cell factories to produce and secrete multitudes of recombinant
pharmaceutical proteins, including several of the current top-selling drugs. Due to the …

The biopharmaceutical market is growing faster than ever, with two production systems
competing for market dominance: mammalian cells and microorganisms. In recent years …

Genome-scale target identification promises to guide microbial cell factory engineering for
higher-titer production of biomolecules such as recombinant proteins (r-protein), but …

Monoclonal antibodies, antibody fragments and fusion proteins derived thereof have
revolutionized the practice of medicine. Major challenges faced by the biopharmaceutical …

Microbial proteins are promising substitutes for animal-and plant-based proteins. S.
cerevisiae, a generally recognized as safe (GRAS) microorganism, has been frequently …

Saccharomyces cerevisiae is a robust cell factory to secrete or surface-display cellulase and
amylase for the conversion of agricultural residues into valuable chemicals. Engineering the …

The successful expression and secretion of recombinant proteins in cell factories
significantly depend on the correct folding of nascent peptides, primarily achieved through …

The rapid expansion of the application of pharmaceutical proteins and industrial enzymes
requires robust microbial workhorses for high protein production. The budding yeast …