Tick immune system: what is known, the interconnections, the gaps, and the challenges

AC Fogaça, G Sousa, DB Pavanelo, E Esteves… - Frontiers in …, 2021 - frontiersin.org
Ticks are ectoparasitic arthropods that necessarily feed on the blood of their vertebrate
hosts. The success of blood acquisition depends on the pharmacological properties of tick …

Host immune responses to salivary components-a critical facet of tick-host interactions

A Ali, I Zeb, A Alouffi, H Zahid, MM Almutairi… - Frontiers in Cellular …, 2022 - frontiersin.org
Tick sialome is comprised of a rich cocktail of bioactive molecules that function as a tool to
disarm host immunity, assist blood-feeding, and play a vibrant role in pathogen …

Ixodes scapularis Tick Saliva Proteins Sequentially Secreted Every 24 h during Blood Feeding

TK Kim, L Tirloni, AFM Pinto, J Moresco… - PLoS neglected …, 2016 - journals.plos.org
Ixodes scapularis is the most medically important tick species and transmits five of the 14
reportable human tick borne disease (TBD) agents in the USA. This study describes LC …

Protease inhibitors in tick saliva: the role of serpins and cystatins in tick-host-pathogen interaction

J Chmelař, J Kotál, H Langhansová… - Frontiers in cellular and …, 2017 - frontiersin.org
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of
research of tick protease inhibitors, which represent important constituents of the proteins …

Sialomes and mialomes: a systems-biology view of tick tissues and tick–host interactions

J Chmelař, J Kotál, S Karim, P Kopacek… - Trends in …, 2016 - cell.com
Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick
salivary glands and other tissues involved in host–pathogen interactions has revealed a …

Defensins as a promising class of tick antimicrobial peptides: a scoping review

J Wu, X Zhou, Q Chen, Z Chen, J Zhang, L Yang… - Infectious Diseases of …, 2022 - Springer
Background Ticks are hematophagous parasites that transmit an extensive range of
pathogens to their vertebrate hosts. Ticks can destroy invading microorganisms or alleviate …

An Insight into the Sialome of the Lone Star Tick, Amblyomma americanum, with a Glimpse on Its Time Dependent Gene Expression

S Karim, JMC Ribeiro - PloS one, 2015 - journals.plos.org
Hard ticks feed for several days or weeks on their hosts. Blood feeding is assisted by tick
saliva, which is injected in the host skin regularly, alternating with blood ingestion. Tick …

All for one and one for all on the tick–host battlefield

J Chmelař, J Kotál, J Kopecký, JHF Pedra… - Trends in …, 2016 - cell.com
The saliva of ixodid ticks contains a mixture of bioactive molecules that target a wide
spectrum of host defense mechanisms to allow ticks to feed on the vertebrate host for …

Tissue- and time-dependent transcription in Ixodes ricinus salivary glands and midguts when blood feeding on the vertebrate host

M Kotsyfakis, A Schwarz, J Erhart, JMC Ribeiro - Scientific reports, 2015 - nature.com
Ixodes ricinus is a tick that transmits the pathogens of Lyme and several arboviral diseases.
Pathogens invade the tick midgut, disseminate through the hemolymph and are transmitted …

Sialome diversity of ticks revealed by RNAseq of single tick salivary glands

J Perner, S Kropáčková, P Kopáček… - PLoS neglected …, 2018 - journals.plos.org
Ticks salivate while feeding on their hosts. Saliva helps blood feeding through host anti-
hemostatic and immunomodulatory components. Previous transcriptomic and proteomic …