Synthetic heterocyclic candidates as promising α-glucosidase inhibitors: An overview
M Dhameja, P Gupta - European journal of medicinal chemistry, 2019 - Elsevier
Abstract α-Glucosidase enzyme inhibition is an effective therapeutic decorum in the
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
treatment of type 2 diabetes mellitus. Since 1990, three α-glucosidase inhibitors are known …
Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
Synthesis, in vitro α-amylase, α-glucosidase activities and molecular docking study of new benzimidazole bearing thiazolidinone derivatives
We have synthesized a series of benzimidazole bearing thiazolidinone derivatives (1-20),
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
characterized through NMR and HREI-MS and screened against α-glucosidase and α …
Fused azoloazines with antidiabetic activity
VL Rusinov, IM Sapozhnikova, AA Spasov… - Russian Chemical …, 2022 - Springer
The purpose of this review is to summarize drugs containing an azoloazine moiety and
exhibiting antidiabetic activity. The review includes azoloazines active against dipeptidyl …
exhibiting antidiabetic activity. The review includes azoloazines active against dipeptidyl …
Synthesis, in vitro evaluation and molecular docking studies of novel triazine-triazole derivatives as potential α-glucosidase inhibitors
G Wang, Z Peng, J Wang, X Li, J Li - European journal of medicinal …, 2017 - Elsevier
A novel series of triazine-triazole derivatives 7a–7m were synthesized, characterized by 1 H
NMR and evaluated for their α-glucosidase inhibitory activity. All the synthesized …
NMR and evaluated for their α-glucosidase inhibitory activity. All the synthesized …
Isatin based Schiff bases as inhibitors of α-glucosidase: Synthesis, characterization, in vitro evaluation and molecular docking studies
Abstract Isatin base Schiff bases (1–20) were synthesized, characterized by 1 H NMR and
EI/MS and evaluated for α-glucosidase inhibitory potential. Out of these twenty (20) …
EI/MS and evaluated for α-glucosidase inhibitory potential. Out of these twenty (20) …
Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
Bio-oriented synthesis of novel polyhydroquinoline derivatives as α-glucosidase inhibitor for management of diabetes
Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
Synthesis and biological evaluation of coumarin derivatives as α-glucosidase inhibitors
XT Xu, XY Deng, J Chen, QM Liang, K Zhang… - European Journal of …, 2020 - Elsevier
In this study, two series of coumarin derivatives 5a∼ i and 6a∼ i were synthesized, and their
inhibitory activity against α-glucosidase was determined. The results indicated that most of …
inhibitory activity against α-glucosidase was determined. The results indicated that most of …
Synthesis of Novel 2,3-Dihydro-1,5-Benzothiazepines as α-Glucosidase Inhibitors: In Vitro, In Vivo, Kinetic, SAR, Molecular Docking, and QSAR Studies
In the present study, a series of 2, 3-dihydro-1, 5-benzothiazepine derivatives 1B–14B has
been synthesized sand characterized by various spectroscopic techniques. The enzyme …
been synthesized sand characterized by various spectroscopic techniques. The enzyme …