Plenty of immune cells infiltrate into the tumor microenvironment (TME) during tumor
progression, in which myeloid-derived suppressor cells (MDSCs) represent a …

The emergence of disseminated metastases remains the primary cause of mortality in
cancer patients. Formation of the pre-metastatic niche (PMN), which precedes the …

Drug resistance remains the major obstacle limiting the effectiveness of chemotherapy for
esophageal squamous cell carcinoma (ESCC)[1]. However, how stromal cells cooperate …

Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the
immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent …

Cancer stem cells play a critical role in colorectal cancer (CRC) progression. Myeloid‐
derived suppressor cells (MDSCs) promote tumor progression through multiple mechanisms …

Lung cancer (LC) is the leading cause of cancer-related death worldwide due to its late
diagnosis and poor outcomes. As has been found for other types of tumors, there is …

We previously identified that the development of early-stage myeloid-derived suppressor
cells (eMDSCs) in breast cancer with high IL-6 (IL-6high) expression was correlated with the …

Myeloid‐derived suppressor cells (MDSCs) are traditionally considered among the major
components of the immunosuppressive tumor microenvironment (TME). However, there is …

Background Myeloid-derived suppressor cells (MDSCs) participate in tumor-elicited
immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby …

MiRNA is a type of small non-coding RNA, by regulating downstream gene expression that
affects the progression of multiple diseases, especially cancer. MiRNA can participate in the …