VDAC regulation of mitochondrial calcium flux: From channel biophysics to disease

WM Rosencrans, M Rajendran, SM Bezrukov… - Cell calcium, 2021 - Elsevier
Voltage-dependent anion channel (VDAC), the most abundant mitochondrial outer
membrane protein, is important for a variety of mitochondrial functions including metabolite …

VDAC modulation of cancer metabolism: advances and therapeutic challenges

KA Heslop, V Milesi, EN Maldonado - Frontiers in Physiology, 2021 - frontiersin.org
Most anionic metabolites including respiratory substrates, glycolytic adenosine triphosphate
(ATP), and small cations that enter mitochondria, and mitochondrial ATP moving to the …

Adverse effects of metformin from diabetes to COVID-19, cancer, neurodegenerative diseases, and aging: is VDAC1 a common target?

V Shoshan-Barmatz, U Anand, E Nahon-Crystal… - Frontiers in …, 2021 - frontiersin.org
Metformin has been used for treating diabetes mellitus since the late 1950s. In addition to its
antihyperglycemic activity, it was shown to be a potential drug candidate for treating a range …

TSPO protein binding partners in bacteria, animals, and plants

C Hiser, BL Montgomery, S Ferguson-Miller - Journal of Bioenergetics and …, 2021 - Springer
The ancient membrane protein TSPO is phylogenetically widespread from archaea and
bacteria to insects, vertebrates, plants, and fungi. TSPO's primary amino acid sequence is …

Mitochondrial VOLTAGE-DEPENDENT ANION CHANNEL 3 regulates stomatal closure by abscisic acid signaling

H Qin, W Yang, Z Liu, Y Ouyang, X Wang… - Plant …, 2024 - academic.oup.com
Abstract In Arabidopsis (Arabidopsis thaliana), stomatal closure mediated by abscisic acid
(ABA) is redundantly controlled by ABA receptor family proteins (PYRABACTIN …

Causes and consequences of endogenous hypoxia on growth and metabolism of developing maize kernels

M Langer, A Hilo, JC Guan, KE Koch, H Xiao… - Plant …, 2023 - academic.oup.com
Maize (Zea mays) kernels are the largest cereal grains, and their endosperm is severely
oxygen deficient during grain fill. The causes, dynamics, and mechanisms of acclimation to …

HSP70‐16 and VDAC3 jointly inhibit seed germination under cold stress in Arabidopsis

M Ashraf, Q Mao, J Hong, L Shi, X Ran… - Plant, Cell & …, 2021 - Wiley Online Library
Abscisic acid (ABA) transport plays a crucial role in seed germination under unfavourable
conditions such as cold stress. Both heat shock protein 70 (HSP70) and voltage‐dependent …

CIPK9 targets VDAC3 and modulates oxidative stress responses in Arabidopsis

P Kanwar, SK Sanyal, S Mahiwal, B Ravi… - The Plant …, 2022 - Wiley Online Library
SUMMARY Calcium (Ca2+) is widely recognized as a key second messenger in mediating
various plant adaptive responses. Here we show that calcineurin B‐like interacting protein …

Molecular response and evolution of plant anion transport systems to abiotic stress

W Jiang, T Tong, X Chen, F Deng, F Zeng, R Pan… - Plant Molecular …, 2022 - Springer
Key message We propose that anion channels are essential players for green plants to
respond and adapt to the abiotic stresses associated changing climate via reviewing the …

Voltage-dependent anion channel 3 (VDAC3) mediates P. syringae induced ABA-SA signaling crosstalk in Arabidopsis thaliana

N Singh, B Ravi, LK Saini, GK Pandey - Plant Physiology and Biochemistry, 2024 - Elsevier
Pathogen severely affects plant mitochondrial processes including respiration, however, the
roles and mechanism of mitochondrial protein during the immune response remain largely …