Protein stability is a topic of major interest for the biotechnology, pharmaceutical and food
industries, in addition to being a daily consideration for academic researchers studying …

Protein fusion tags are indispensible tools used to improve recombinant protein expression
yields, enable protein purification, and accelerate the characterization of protein structure …

Avoidance of apoptosis is critical for the development and sustained growth of tumours. The
pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but …

The p53 pro-apoptotic tumour suppressor is mutated or functionally altered in most cancers.
In epithelial tumours induced by 'high-risk'mucosal human papilloma viruses, including …

Adenosine monophosphate (AMP)–activated protein kinase (AMPK) regulates metabolism
in response to the cellular energy states. Under energy stress, AMP stabilizes the active …

Two major glycosaminoglycan types, heparan sulfate (HS) and chondroitin sulfate (CS),
control many aspects of development and physiology in a type-specific manner. HS and CS …

The exact function of human gasdermin-B (GSDMB), which regulates differentiation and
growth of epithelial cells, is yet to be elucidated. In human epidermal growth factor receptor …

Classic mechanisms for membrane fusion involve transmembrane proteins that assemble
into complexes and dynamically alter their conformation to bend membranes, leading to …

Since the introduction of recombinant protein expression in the second half of the 1970s, the
growth of the biopharmaceutical field has been rapid and protein therapeutics has come to …

Since the dawn of time, or at least the dawn of recombinant DNA technology (which for many
of today's scientists is the same thing), investigators have been cloning and expressing …