Inhibitors of the ATPase p97/VCP: From basic research to clinical applications
Protein homeostasis deficiencies underlie various cancers and neurodegenerative
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …
diseases. The ubiquitin-proteasome system (UPS) and autophagy are responsible for most …
The AAA+ ATPase p97, a cellular multitool
L Stach, PS Freemont - Biochemical Journal, 2017 - portlandpress.com
The AAA+ (ATPases associated with diverse cellular activities) ATPase p97 is essential to a
wide range of cellular functions, including endoplasmic reticulum-associated degradation …
wide range of cellular functions, including endoplasmic reticulum-associated degradation …
Mechanistic insight into substrate processing and allosteric inhibition of human p97
Abstract p97 processes ubiquitinated substrates and plays a central role in cellular protein
homeostasis. Here, we report a series of cryo-EM structures of the substrate-engaged …
homeostasis. Here, we report a series of cryo-EM structures of the substrate-engaged …
Valosin-containing protein (VCP)/p97: a prognostic biomarker and therapeutic target in cancer
S Costantini, F Capone, A Polo, P Bagnara… - International journal of …, 2021 - mdpi.com
Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …
chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane …
p97: an emerging target for cancer, neurodegenerative diseases, and viral infections
The AAA+ ATPase, p97, also referred to as VCP, plays an essential role in cellular
homeostasis by regulating endoplasmic reticulum-associated degradation (ERAD) …
homeostasis by regulating endoplasmic reticulum-associated degradation (ERAD) …
VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in …
Valosin-containing protein (VCP) or p97, a member of AAA-ATPase protein family, has been
associated with various cellular functions including endoplasmic reticulum-associated …
associated with various cellular functions including endoplasmic reticulum-associated …
C–H alkylation reactions of indoles mediated by Pd (ii) and norbornene: applications and recent developments
M Wegmann, M Henkel, T Bach - Organic & Biomolecular Chemistry, 2018 - pubs.rsc.org
The Catellani reaction enables an ortho-C–H activation based on oxidative addition of Pd
(0) and an intermediary carbopalladation of norbornene. Among its variants, the recently …
(0) and an intermediary carbopalladation of norbornene. Among its variants, the recently …
Targeting p97 to disrupt protein homeostasis in cancer
PH Vekaria, T Home, S Weir, FJ Schoenen… - Frontiers in …, 2016 - frontiersin.org
Cancer cells are addicted to numerous non-oncogenic traits that enable them to thrive.
Proteotoxic stress is one such non-oncogenic trait that is experienced by all tumor cells …
Proteotoxic stress is one such non-oncogenic trait that is experienced by all tumor cells …
Modulating protein–protein interaction networks in protein homeostasis
Protein–protein interactions (PPIs) occur in complex networks. These networks are highly
dependent on cellular context and can be extensively altered in disease states such as …
dependent on cellular context and can be extensively altered in disease states such as …