Flagellin as a vaccine adjuvant

B Cui, X Liu, Y Fang, P Zhou, Y Zhang… - Expert review of …, 2018 - Taylor & Francis
Introduction: Bacterial flagellin, as a pathogen-associated molecular pattern (PAMP), can
activate both innate and adaptive immunity. Its unique structural characteristics endow an …

Biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines

PM Moyle - Biotechnology advances, 2017 - Elsevier
Traditional vaccination approaches (eg live attenuated or killed microorganisms) are among
the most effective means to prevent the spread of infectious diseases. These approaches …

Poly (hydrophobic amino acid) Conjugates for the Delivery of Multiepitope Vaccine against Group A Streptococcus

A Azuar, MA Shibu, N Adilbish, N Marasini… - Bioconjugate …, 2021 - ACS Publications
Peptide-based vaccines are composed of small, defined, antigenic peptide epitopes. They
are designed to induce well-controlled immune responses. Multiple epitopes are often …

Flagellin and pilin immunization against multi-drug resistant Pseudomonas aeruginosa protects mice in the burn wound sepsis model

F Korpi, FB Hashemi, G Irajian, MJ Fatemi, P Laghaei… - Immunology letters, 2016 - Elsevier
Pseudomonas aeruginosa is a formidable pathogen and a major threat to burn patients.
Antimicrobial therapy is often unsuccessful because P. aeruginosa can develop multi-drug …

[HTML][HTML] In silico evaluation of PLAC1-fliC as a chimeric vaccine against breast cancer

M Taheri-Anganeh, A Amiri… - Iranian Biomedical …, 2020 - ncbi.nlm.nih.gov
Background: Breast cancer is one of the most prevalent cancers among women. Common
cancer treatment methods are not effective enough, and there is a need for a more efficient …

A chimeric vaccine targeting Pseudomonas aeruginosa virulence factors protects mice against lethal infection

F Korpi, G Irajian, F Forouhi, T Mohammadian - Microbial Pathogenesis, 2023 - Elsevier
Pseudomonas aeruginosa is an important and hazardous nosocomial pathogen in
respiratory tract infections and rapidly achieves antibiotic resistance, so it is necessary to …

Immunization with Bivalent Flagellin Protects Mice against Fatal Pseudomonas aeruginosa Pneumonia

B Behrouz, FB Hashemi, MJ Fatemi… - Journal of …, 2017 - Wiley Online Library
Pseudomonas aeruginosa lung infections present a major challenge to healthcare systems
worldwide because they are commonly associated with high morbidity and mortality. Here …

Preparation of Pseudomonas aeruginosa alginate-flagellin immunoconjugate

S Faezi, AR Bahrmand, M Mahdavi, SD Siadat… - Biologicals, 2017 - Elsevier
Mucoid strains of Pseudomonas aeruginosa are closely associated with chronic pulmonary
infections. In this report we describe a straightforward approach to conjugate high molecular …

Перспективные направления использования препаратов на основе рекомбинантного флагеллина

ГА Софронов, ЕВ Мурзина, ВН Болехан… - Медицинский …, 2017 - elibrary.ru
В статье представлены результаты анализа современной научной литературы,
посвященной изучению биологической активности бактериального белка флагеллина с …

A trivalent vaccine consisting of “flagellin A+ B and pilin” protects against Pseudomonas aeruginosa infection in a murine burn model

FB Hashemi, B Behrouz, G Irajian, P Laghaei… - Microbial …, 2020 - Elsevier
Pseudomonas aeruginosa is a common nosocomial pathogen in burn patients, and rapidly
achieves antibiotic resistance, and thus, developing an effective vaccine is critically …