Endocrine pituitary cells are neuronlike; they express numerous voltage-gated sodium,
calcium, potassium, and chloride channels and fire action potentials spontaneously …

Astroglia, a heterogeneous type of neuroglia, play key homeostatic functions in the central
nervous system (CNS) and represent an important defence system. Impaired homeostatic …

Although cAMP is well known to regulate exocytosis in many secretory cells, its direct target
in the exocytotic machinery is not known. Here we show that cAMP-GEFII, a cAMP sensor …

How does cyclic AMP potentiate insulin secretion from pancreatic islet β-cells? This question
is fundamental to understanding how hormones such as glucagon, which elevates cAMP1 …

The mechanisms by which cAMP stimulates Ca (2+)-dependent insulin secretion were
investigated by combining measurements of whole-cell Ca2+ currents, the cytoplasmic free …

Atrazine, one of the most commonly used herbicides worldwide, acts as an endocrine
disruptor, but the mechanism of its action has not been characterized. In this study, we show …

Ketamine is an antidepressant with rapid therapeutic onset and long-lasting effect, although
the underlying mechanism (s) remain unknown. Using FRET-based nanosensors we found …

In order to understand exocytosis and endocytosis, it is necessary to study these processes
directly. An elegant way to do this is by measuring plasma membrane capacitance (C m), a …

We studied the effects of TRH on the cytosolic free calcium concentration ([Ca2+] i) of female
rat pituitary prolactin-secreting (lactotroph) and GH-secreting (somatotroph) cells in the early …

We used fluorescence imaging of individual exocytic events together with electron
microscopy to study the regulation of dense core granule-to-plasma membrane fusion and …