BRPF1-KAT6A/KAT6B complex: molecular structure, biological function and human disease

G Zu, Y Liu, J Cao, B Zhao, H Zhang, L You - Cancers, 2022 - mdpi.com
Simple Summary BRPF1 (also named as BR140) was identified 28 years ago, and it was not
until the past 5 years that its mutations in humans caught increasing attention. Those …

MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain

DC Becht, BJ Klein, A Kanai, SM Jang, KL Cox… - Nature …, 2023 - nature.com
Human acetyltransferases MOZ and MORF are implicated in chromosomal translocations
associated with aggressive leukemias. Oncogenic translocations involve the far amino …

Direct observation of surface charge and stiffness of human metaphase chromosomes

S Roh, T Lee, Y Kim, S Oh, G Lee - Nanoscale Advances, 2023 - pubs.rsc.org
Metaphase chromosomes in which both polynucleotides and proteins are condensed with
hierarchies are closely related to life phenomena such as cell division, cancer development …

Mosaicism in BRPF1‐Related Neurodevelopmental Disorder: Report of Two Sisters and Literature Review

K Bayanbold, G Younger, B Darbro… - Case reports in …, 2023 - Wiley Online Library
Bromodomain and PHD finger containing 1 (BRPF1)‐related neurodevelopmental disorder
is characterized by intellectual disability, developmental delay, hypotonia, dysmorphic facial …

[HTML][HTML] Characterization of multiple interactions between the envelope E protein of SARS-CoV-2 and human BRD4

M Zandian, SM Jang, C Lachance, A Acharya… - STAR protocols, 2022 - Elsevier
Summary The SARS-CoV-2 envelope (E) protein hijacks human BRD4 (bromodomain and
extra-terminal domain protein 4). Here, we describe a protocol to characterize the interaction …