COVID-19: A review of therapeutic strategies and vaccine candidates
The world is engulfed by one of the most widespread and significant public health crises in
decades as COVID-19 has become among the leading causes of death internationally. The …
decades as COVID-19 has become among the leading causes of death internationally. The …
Depression and obesity: evidence of shared biological mechanisms
Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …
tend to co-occur within individuals. The relationship between these conditions is …
Long-term side effects of glucocorticoids
M Oray, K Abu Samra, N Ebrahimiadib… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Glucocorticoids represent the standard therapy for reducing inflammation and
immune activation in various diseases. However, as with any potent medication, they are not …
immune activation in various diseases. However, as with any potent medication, they are not …
Stress and obesity: are there more susceptible individuals?
Abstract Purpose of Review Stress has long been suspected to be interrelated to
(abdominal) obesity. However, interindividual differences in this complex relationship exist …
(abdominal) obesity. However, interindividual differences in this complex relationship exist …
Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?
It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …
Obesity and psychological distress
The relationship between high body weight and mental health has been studied for several
decades. Improvements in the quality of epidemiological, mechanistic and psychological …
decades. Improvements in the quality of epidemiological, mechanistic and psychological …
Metabolomics profile in depression: a pooled analysis of 230 metabolic markers in 5283 cases with depression and 10,145 controls
M Bot, Y Milaneschi, T Al-Shehri, N Amin… - Biological …, 2020 - Elsevier
Background Depression has been associated with metabolic alterations, which adversely
impact cardiometabolic health. Here, a comprehensive set of metabolic markers …
impact cardiometabolic health. Here, a comprehensive set of metabolic markers …
Chronic stress and A lzheimer's disease: the interplay between the hypothalamic–pituitary–adrenal axis, genetics and microglia
Chronic psychosocial stress is increasingly being recognised as a risk factor for sporadic
Alzheimer's disease (AD). The hypothalamic–pituitary–adrenal axis (HPA axis) is the major …
Alzheimer's disease (AD). The hypothalamic–pituitary–adrenal axis (HPA axis) is the major …
Approach to the patient: diagnosis of Cushing syndrome
Cushing syndrome results from supraphysiological exposure to glucocorticoids and is
associated with significant morbidity and mortality. The pathogenesis includes …
associated with significant morbidity and mortality. The pathogenesis includes …
Short-term dose and duration-dependent glucocorticoid risk for cardiovascular events in glucocorticoid-naive patients with rheumatoid arthritis
Objectives Rheumatoid arthritis (RA), along with glucocorticoid use, is associated with
cardiovascular disease. Cardiovascular safety of glucocorticoids in RA is controversial and …
cardiovascular disease. Cardiovascular safety of glucocorticoids in RA is controversial and …