Acute kidney injury (AKI) is a common and frequently fatal illness in critically ill patients. The
reliance on daily measurements of serum creatinine as a surrogate of glomerular filtration …

Determination of glomerular filtration rate (GFR) in conscious mice is cumbersome for the
experimenter and stressful for the animals. Here we report on a simple new technique …

Determination of the urinary or plasma clearance of exogenous renal markers, such as
inulin or iohexol, is considered to be the gold standard for glomerular filtration rate (GFR) …

Abstract Background. Inulin/sinistrin (I/S) clearance is a gold standard for an accurate
assessment of glomerular filtration rate (GFR). Here we describe and validate an approach …

Measuring renal function in laboratory animals using blood and/or urine sampling is not only
labor-intensive but puts also a strain on the animal. Several approaches for fluorescence …

Chronic kidney disease (CKD) is one of the most common chronic diseases worldwide, with
increasing rates of morbidity and mortality. Thus, early detection is essential to prevent …

The rapid diagnosis and quantification of acute kidney injury (AKI) severity remain high
clinical priorities. By combining intravital fluorescent ratiometric two-photon kidney imaging …

Control of microvascular reactivity by 5-hydroxytryptamine (5-HT; serotonin) is complex and
may depend on vascular bed type and 5-HT receptors. 5-HT receptors consist of seven …

There is an evident and growing medical need for an accurate determination of kidney
function for a broad spectrum of indications. The glomerular filtration rate (GFR) is the most …

Recently, new methods for assessing renal function in conscious mice (transcutaneous
assessment) and for counting and sizing all glomeruli in whole kidneys (MRI) have been …