Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …

Senescence of the immune system is characterized by a state of chronic, subclinical, low-
grade inflammation termed 'inflammaging', with increased levels of proinflammatory …

Background MicroRNAs (miRNAs) and circulating cell-free mitochondrial DNA (ccf-mtDNA)
have attracted interest as biological markers of affective disorders. In response to stress, it is …

Background Frailty, a clinical syndrome commencing at midlife, is a risk for morbidity and
mortality. Little is known about the factors that contribute to the chronic inflammatory state …

Background Dementia and frailty are common age-related syndromes often linked to chronic
inflammation. Identifying the biological factors and pathways that contribute to chronic …

Mitochondrial dysfunction occurs during aging and may play a role, by distinct mechanisms,
in the loss of intrinsic capacity (IC), operationalized through 5 domains: locomotion …

Background Disrupted cellular communication, inflammatory responses and mitochondrial
dysfunction are consistently observed in late-life depression (LLD). Exosomes (EXs) …

Abstract Extracellular Genomic Materials (EGMs) are the nucleic acids secreted or released
from all types of cells by endogenous or exogenous stimuli through varying mechanisms into …

Introduction The analysis of the role of the mitochondria in oxidative damage and skin aging
has been a significant aspect of dermatological research. Mitochondria generate most …

Background Frailty increases the incidence of geriatric syndromes and even the risk of death
in old adults. However, the diagnostic criteria for frailty are inconsistent because of complex …