Our understanding of the pathogenesis of diseases has advanced enormously in recent
decades. As a consequence, drug discovery has gradually shifted from an entirely …

Oxidative stress is now recognized as accountable for redox regulation involving reactive
oxygen species (ROS) and reactive nitrogen species (RNS). Its role is pivotal for the …

Minocycline is commonly used to inhibit microglial activation. It is widely accepted that
activated microglia exert dual functions, that is, pro-inflammatory (M1) and anti-inflammatory …

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …

Microglial activation is implicated in the pathogenesis of ALS and can be detected in animal
models of the disease that demonstrate increased survival when treated with anti …

Here we report in vivo evidence of a neuroprotective role of proliferating microglial cells in
cerebral ischemia. Using transgenic mice expressing a mutant thymidine kinase form of …

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of
adults which preferentially attacks the neuromotor system. Riluzole has been used as the …

The capacity of minocycline to alleviate disease for several neurological disorders in
animals is increasingly being recognised. Indeed, that one drug alone can attenuate the …

Gain-of-function mutations in the Cu, Zn-superoxide dismutase (SOD1) gene are implicated
in progressive motor neuron death and paralysis in one form of inherited amyotrophic lateral …

Growing evidence suggests that galectin-3 is involved in fine tuning of the inflammatory
responses at the periphery, however, its role in injured brain is far less clear. Our previous …