Drug resistance mechanisms and novel drug targets for tuberculosis therapy
Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …
Recent advances in molecular diagnostics and understanding mechanisms of drug resistance in nontuberculous mycobacterial diseases
HJ Huh, SY Kim, BW Jhun, SJ Shin, WJ Koh - Infection, Genetics and …, 2019 - Elsevier
Accumulating evidence suggests that human infections caused by nontuberculous
mycobacteria (NTM) are increasing worldwide, indicating that NTM disease is no longer …
mycobacteria (NTM) are increasing worldwide, indicating that NTM disease is no longer …
Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol
L Zhang, Y Zhao, Y Gao, L Wu, R Gao, Q Zhang… - Science, 2020 - science.org
The arabinosyltransferases EmbA, EmbB, and EmbC are involved in Mycobacterium
tuberculosis cell wall synthesis and are recognized as targets for the anti-tuberculosis drug …
tuberculosis cell wall synthesis and are recognized as targets for the anti-tuberculosis drug …
Relapse versus reinfection of recurrent tuberculosis patients in a national tuberculosis specialized hospital in Beijing, China
Z Zong, F Huo, J Shi, W Jing, Y Ma, Q Liang… - Frontiers in …, 2018 - frontiersin.org
Tuberculosis (TB) recurrence can result from either relapse of an original infection or
exogenous reinfection with a new strain of Mycobacterium tuberculosis (MTB). The aim of …
exogenous reinfection with a new strain of Mycobacterium tuberculosis (MTB). The aim of …
Occurrence of disputed rpoB mutations among Mycobacterium tuberculosis isolates phenotypically susceptible to rifampicin in a country with a low incidence of …
NM Al-Mutairi, S Ahmad, E Mokaddas, HS Eldeen… - BMC infectious …, 2019 - Springer
Background Accurate drug susceptibility testing (DST) of Mycobacterium tuberculosis in
clinical specimens and culture isolates to first-line drugs is crucial for diagnosis and …
clinical specimens and culture isolates to first-line drugs is crucial for diagnosis and …
Mycobacterial ethambutol responsive genes and implications in antibiotics resistance
X Xiang, Z Gong, W Deng, Q Sun, J Xie - Journal of Drug Targeting, 2021 - Taylor & Francis
Abstract Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis
(TB), remains a formidable threat in mortality and morbidity worldwide. Ethambutol (EMB) is …
(TB), remains a formidable threat in mortality and morbidity worldwide. Ethambutol (EMB) is …
[HTML][HTML] Whole genome enrichment approach for rapid detection of Mycobacterium tuberculosis and drug resistance-associated mutations from direct sputum …
L Soundararajan, P Kambli, S Priyadarshini, B Let… - Tuberculosis, 2020 - Elsevier
Tuberculosis is the leading cause of death among infectious diseases worldwide. Detection
of Mycobacterium tuberculosis (Mtb), using routine culture-based methods is time …
of Mycobacterium tuberculosis (Mtb), using routine culture-based methods is time …
Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico
CF Madrazo-Moya, I Cancino-Muñoz… - PLoS …, 2019 - journals.plos.org
Background Whole genome sequencing (WGS) has been proposed as a tool for diagnosing
drug resistance in tuberculosis. However, reports of its effectiveness in endemic countries …
drug resistance in tuberculosis. However, reports of its effectiveness in endemic countries …
Genetic diversity and drug susceptibility profiles of Mycobacterium tuberculosis obtained from Saint Peter's TB specialized Hospital, Ethiopia
D Damena, S Tolosa, M Hailemariam, A Zewude… - PloS one, 2019 - journals.plos.org
Background Tuberculosis (TB) is one of the major public health problems in Ethiopia. Data
on genetic diversity and resistance profile of circulating TB strains is critical for informing the …
on genetic diversity and resistance profile of circulating TB strains is critical for informing the …
Frequency of codon 306 mutations in embB gene of Mycobacterium tuberculosis resistant to ethambutol: a systematic review and meta-analysis
B Mohammadi, R Ramazanzadeh… - International Journal of …, 2020 - journals.lww.com
Background: Ethambutol (EMB) resistance is a major concern in patients with tuberculosis
(TB). The aim of this study was to determine the frequency rate of mutations in the embB306 …
(TB). The aim of this study was to determine the frequency rate of mutations in the embB306 …