Elevated cortisol in a subset of depressed patients is an enduring and well-replicated
finding. Much interest has focused on the possible effects of depression on the …

Stress is commonly associated with a variety of psychiatric conditions, including major
depression, and with chronic medical conditions, including diabetes and insulin resistance …

Background: One of the most enduring and replicated findings in biological psychiatry is
activation of the hypothalamic-pituitary-adrenal (HPA) axis in a subset of patients with major …

Abstract Knowledge of psychiatric disease genetics has advanced rapidly during the past
decade with the advent of genome-wide association studies (GWAS). However, less …

High cortisol levels are found in severe mood disorders, particularly bipolar disorder.
Hypercortisolaemia may cause or exacerbate both neurocognitive impairment and …

Dias VV, Balanzá‐Martinez V, Soeiro‐de‐Souza MG, Moreno RA, Figueira ML, Machado‐
Vieira R, Vieta E. Pharmacological approaches in bipolar disorders and the impact on …

Depression is a major emotional disorder that has a detrimental effect on quality of life. The
chronic mild stress (CMS)-depression model was adopted in rats to evaluate the …

В современной медицине все меньше остается нозологических единиц, которые,
несмотря на самый современный подход и востребованность их изучения, до сих пор …

Cortisol, commonly known as the" stress hormone," plays a critical role in the body's
response to stress. Elevated cortisol levels have been associated with various mental …

Background Antiglucocorticoids may have antidepressant effects and have been reported to
be efficacious in the treatment of severe psychiatric disorders. The efficacy and safety of …