Dendritic cells (DCs) are a unique class of immune cells that act as a bridge between innate
and adaptive immunity. The discovery of DCs by Cohen and Steinman in 1973 laid the …

Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens
and to receive feedback control from adaptive immune cells. Although it was long believed …

Presentation of exogenous antigens on MHC-I molecules, termed cross-presentation, is
essential for cytotoxic CD8+ T cell responses. In mice, dendritic cells (DCs) that arise from …

Among all immune cells, dendritic cells (DC) are the most potent APCs in the immune
system and are central players of the adaptive immune response. There are phenotypically …

The method of choice for the development of new vaccines is to target distinct dendritic cell
subsets with antigen in vivo and to harness their function in situ to enhance cell-mediated …

Dendritic cells (DC) represent a heterogeneous population of antigen-presenting cells that
are crucial in initiating and shaping immune responses. Although all DC are capable of …

Despite significant effort, the development of effective vaccines inducing strong and durable
T-cell responses against intracellular pathogens and cancer cells has remained a …

Antigen cross-presentation, the process in which exogenous antigens are presented on
MHC class I molecules, is crucial for the generation of effector CD8+ T cell responses …

Cross-priming refers to the induction of primary cytotoxic CD8+ T cell responses to antigens
that are not expressed in antigen presenting cells (APCs) responsible for T cell priming …

Antigen cross-presentation describes the process through which dendritic cells (DCs)
acquire exogenous antigens for presentation on MHC class I molecules. The ability to cross …