G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …
It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved in signal transmission, have recently emerged as crucial players in tumour growth and …
M Li-Weber - Cancer treatment reviews, 2009 - Elsevier
Traditional Chinese medicines have been recently recognized as a new source of anticancer drugs and new chemotherapy adjuvant to enhance the efficacy of chemotherapy …
M O'Hayre, MS Degese, JS Gutkind - Current opinion in cell biology, 2014 - Elsevier
G protein-coupled receptors (GPCRs) play a central role in signal transmission, thereby controlling many facets of cellular function. Overwhelming evidence now implicates GPCRs …
Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying receptor family and mediate many physiological processes, their role in tumor biology is …
AJ Cockbain, GJ Toogood, MA Hull - Gut, 2012 - gut.bmj.com
Omega (ω)-3 polyunsaturated fatty acids (PUFAs) are naturally occurring substances that are well tolerated and have been used extensively for the prevention of cardiovascular …
J Gandhi, L Khera, N Gaur, C Paul, R Kaul - Frontiers in microbiology, 2017 - frontiersin.org
Chronic inflammation is recognized as a threat factor for cancer progression. Release of inflammatory molecules generates microenvironment which is highly favorable for …
Y Kitase, L Barragan, H Qing, S Kondoh… - Journal of Bone and …, 2010 - academic.oup.com
Glucocorticoids are known to induce osteocyte apoptosis, whereas mechanical loading has been shown to sustain osteocyte viability. Here we show that mechanical loading in the form …