An insight into GPCR and G-proteins as cancer drivers

PK Chaudhary, S Kim - Cells, 2021 - mdpi.com
G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers

N Arang, JS Gutkind - FEBS letters, 2020 - Wiley Online Library
G protein‐coupled receptors (GPCRs) and heterotrimeric G proteins play central roles in a
diverse array of cellular processes. As such, dysregulation of GPCRs and their coupled …

The COX-2/PGE 2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

A Greenhough, HJM Smartt, AE Moore… - …, 2009 - academic.oup.com
It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

G-protein-coupled receptors and cancer

RT Dorsam, JS Gutkind - Nature reviews cancer, 2007 - nature.com
G-protein-coupled receptors (GPCRs), the largest family of cell-surface molecules involved
in signal transmission, have recently emerged as crucial players in tumour growth and …

New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

M Li-Weber - Cancer treatment reviews, 2009 - Elsevier
Traditional Chinese medicines have been recently recognized as a new source of
anticancer drugs and new chemotherapy adjuvant to enhance the efficacy of chemotherapy …

Novel insights into G protein and G protein-coupled receptor signaling in cancer

M O'Hayre, MS Degese, JS Gutkind - Current opinion in cell biology, 2014 - Elsevier
G protein-coupled receptors (GPCRs) play a central role in signal transmission, thereby
controlling many facets of cellular function. Overwhelming evidence now implicates GPCRs …

G protein-coupled receptors in cancer

R Bar-Shavit, M Maoz, A Kancharla, JK Nag… - International journal of …, 2016 - mdpi.com
Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying
receptor family and mediate many physiological processes, their role in tumor biology is …

Omega-3 polyunsaturated fatty acids for the treatment and prevention of colorectal cancer

AJ Cockbain, GJ Toogood, MA Hull - Gut, 2012 - gut.bmj.com
Omega (ω)-3 polyunsaturated fatty acids (PUFAs) are naturally occurring substances that
are well tolerated and have been used extensively for the prevention of cardiovascular …

Role of modulator of inflammation cyclooxygenase-2 in gammaherpesvirus mediated tumorigenesis

J Gandhi, L Khera, N Gaur, C Paul, R Kaul - Frontiers in microbiology, 2017 - frontiersin.org
Chronic inflammation is recognized as a threat factor for cancer progression. Release of
inflammatory molecules generates microenvironment which is highly favorable for …

Mechanical induction of PGE2 in osteocytes blocks glucocorticoid‐induced apoptosis through both the β‐catenin and PKA pathways

Y Kitase, L Barragan, H Qing, S Kondoh… - Journal of Bone and …, 2010 - academic.oup.com
Glucocorticoids are known to induce osteocyte apoptosis, whereas mechanical loading has
been shown to sustain osteocyte viability. Here we show that mechanical loading in the form …