Dynamic regulation of histone lysine methylation by demethylases

Y Shi, JR Whetstine - Molecular cell, 2007 - cell.com
Recent studies demonstrated that histone methylation is not static but is dynamically
regulated by histone methyltransferases and the newly discovered histone demethylases …

Structure and mechanism of monoamine oxidase

DE Edmondson, A Mattevi, C Binda… - Current medicinal …, 2004 - ingentaconnect.com
Monoamine oxidases A and B (MAO A and MAO B) are mitochondrial outer membrane-
bound flavoproteins that catalyze the oxidative deamination of neurotransmitters and …

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Y Shi, F Lan, C Matson, P Mulligan, JR Whetstine… - Cell, 2004 - cell.com
Posttranslational modifications of histone N-terminal tails impact chromatin structure and
gene transcription. While the extent of histone acetylation is determined by both …

Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B

L De Colibus, M Li, C Binda, A Lustig… - Proceedings of the …, 2005 - National Acad Sciences
The three-dimensional structure of recombinant human monoamine oxidase A (hMAO A) as
its clorgyline-inhibited adduct is described. Although the chain-fold of hMAO A is similar to …

Polyamines Induce Rapid Biosynthesis of Nitric Oxide (NO) in Arabidopsis thaliana Seedlings

NN Tun, C Santa-Catarina, T Begum… - Plant and Cell …, 2006 - academic.oup.com
In this study, we examined the regulation by putrescine, spermidine and spermine of nitric
oxide (NO) biosynthesis in Arabidopsis thaliana seedlings. Using a fluorimetric method …

[HTML][HTML] Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure

J Xu, G Li, P Wang, H Velazquez, X Yao… - The Journal of …, 2005 - Am Soc Clin Investig
The kidney not only regulates fluid and electrolyte balance but also functions as an
endocrine organ. For instance, it is the major source of circulating erythropoietin and renin …

Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures

C Binda, M Li, F Hubálek, N Restelli… - Proceedings of the …, 2003 - National Acad Sciences
Monoamine oxidase B (MAO-B) is an outer mitochondrial membrane-bound enzyme that
catalyzes the oxidative deamination of arylalkylamine neurotransmitters and has been a …

A novel mammalian flavin-dependent histone demethylase

A Karytinos, F Forneris, A Profumo, G Ciossani… - Journal of Biological …, 2009 - ASBMB
Methylation of Lys residues on histone proteins is a well known and extensively
characterized epigenetic mark. The recent discovery of lysine-specific demethylase 1 …

Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases

DE Edmondson, C Binda, J Wang, AK Upadhyay… - Biochemistry, 2009 - ACS Publications
The past decade has brought major advances in our knowledge of the structures and
mechanisms of MAO A and MAO B, which are pharmacological targets for specific inhibitors …

Polyamine metabolism and cancer

T Thomas, TJ Thomas - Journal of cellular and molecular …, 2003 - Wiley Online Library
Polyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are
intricately controlled by biosynthetic and catabolic enzymes. The biosynthetic enzymes are …