The mechanistic target of rapamycin complex 1 (mTORC1), a multi-subunit protein kinase
complex, interrogates growth factor signaling with cellular nutrient and energy status to …

Peroxisome proliferator-activated receptor gamma (PPARγ) is a type II nuclear receptor,
initially recognized in adipose tissue for its role in fatty acid storage and glucose metabolism …

Acute kidney injury (AKI) is defined as a rapid decline in renal function and is characterized
by excessive renal inflammation and programmed death of resident cells. AKI shows high …

Ras homolog enriched in brain (Rheb1), a small GTPase, plays a crucial role in regulating
cell growth, differentiation, and survival. However, the role and mechanisms for Rheb1 in …

Background: Activated fibroblasts are present in the injury response, tumorigenesis, fibrosis,
and inflammation in a variety of tissues and myriad disease types. Summary: During normal …

Cisplatin is one of the most effective antitumor agents, but its clinical use is highly limited by
its severe side effects, especially nephrotoxicity. Recently, the active form of gasdermin D …

Energy metabolism is crucial in maintaining cellular homeostasis and adapting to stimuli for
tubular cells. However, the underlying mechanisms remain largely unknown. Here, we …

Epidemiological studies document strong associations between acute or chronic kidney
injury and kidney tumors. However, whether these associations are linked by causation, and …

Extracellular vesicles (EVs) are a heterogeneous group of membranous structures, which
can be secreted by most cell types. As a product of paracrine secretion, EVs are considered …

Background Progressive fibrosis is the underlying pathophysiological process of CKD, and
targeted prevention or reversal of the profibrotic cell phenotype is an important goal in …