Since the first identification of renin by Tigerstedt and Bergmann in 1898, the renin-
angiotensin system (RAS) has been extensively studied. The current view of the system is …

Remodeling of large and small arteries contributes to the development and complications of
hypertension. The focus of this review is some of the mechanisms involved in the …

Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration.
In contrast to physiological glucose concentration, chronic superphysiological glucose …

Angiotensin-converting enzyme (ACE) is primarily localized (> 90%) in various tissues and
organs, most notably on the endothelium but also within parenchyma and inflammatory …

Aims Elevated blood pressure (EBP) is the most prevalent and potentially modifiable risk
factor for AF, yet little is known of its atrial effects. We aimed to characterize the atrial …

In the last decade, apoptosis (or programmed cell death) has become appreciated as an
important process in the development of the cardiovascular system. Moreover, apoptosis …

On constate que l'apoptose, mort cellulaire programmée, est un événement cellulaire
important dans le développement normal et dans la progression de maladies spécifiques …

Evidence is increasing in hypertensive models for an inflammatory reaction in the
microcirculation with abnormal leukocyte counts and adhesion to the endothelium …

Apoptosis is “suicidal” programmed cell death followed by necrosis, ie cellular degradation.
This review presents a critical evaluation of the methods used for detection of apoptosis and …

It is widely accepted that there are two principal forms of cell death; namely, necrosis and
apoptosis. According to the classical view, necrosis is the major mechanism of …