The endolysosomal system comprises a dynamic constellation of vesicles working together
to sense and interpret environmental cues and facilitate homeostasis. Integrating …

Shigella, the causative agent of bacillary dysentery, subvert cytoskeletal and trafficking
processes to invade and replicate in epithelial cells using an arsenal of bacterial effectors …

Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into
host cells during infection. The effectors modulate host cell machinery to drive uptake of the …

The class I phosphatidylinositol 3-kinase (PI3K)-AKT signaling pathway is a key regulator of
cell survival, growth, and proliferation and is among the most frequently mutated pathways in …

Mast cells localize to mucosal tissues and contribute to innate immune defense against
infection. How mast cells sense, differentiate between, and respond to bacterial pathogens …

ABSTRACT The lipid molecule phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P 2]
controls all aspects of plasma membrane (PM) function in animal cells, from its selective …

Salmonella, a stealthy facultative intracellular pathogen, utilises an array of host immune
evasion strategies. This facilitates successful survival via replicative niche establishment in …

Phosphoinositides are pivotal regulators of vesicular traffic and signaling during
phagocytosis. Phagosome formation, the initial step of the process, is characterized by local …

Highlights•Manipulation of the host cell plasma membrane is critical for infection by
intracellular bacterial pathogens.•Plasma membrane manipulation occurs during bacterial …

Intracellular bacterial pathogens remodel the plasma membrane of eukaryotic cells in order
to establish infection. A common and well‐studied mechanism of plasma membrane …