[HTML][HTML] Harnessing cerebrospinal fluid circulation for drug delivery to brain tissues

GN Kouzehgarani, T Feldsien, HH Engelhard… - Advanced Drug Delivery …, 2021 - Elsevier
Initially thought to be useful only to reach tissues in the immediate vicinity of the CSF
circulatory system, CSF circulation is now increasingly viewed as a viable pathway to deliver …

Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus

SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2024 - Springer
The principles of cerebrospinal fluid (CSF) production, circulation and outflow and regulation
of fluid volumes and pressures in the normal brain are summarised. Abnormalities in these …

Modelling idiopathic intracranial hypertension in rats: contributions of high fat diet and testosterone to intracranial pressure and cerebrospinal fluid production

JH Wardman, MN Jensen, SN Andreassen… - Fluids and Barriers of …, 2023 - Springer
Background Idiopathic intracranial hypertension (IIH) is a condition characterized by
increased intracranial pressure (ICP), impaired vision, and headache. Most cases of IIH …

Outcomes measures in idiopathic intracranial hypertension

SP Mollan, AJ Sinclair - Expert review of neurotherapeutics, 2021 - Taylor & Francis
Introduction: Idiopathic intracranial hypertension is a condition characterized by raised
intracranial pressure, papilledema, and normal neuroimaging (aside from radiological signs …

Morphological alterations of the hypothalamus in idiopathic intracranial hypertension

R Kassubek, D Weinstock, A Behler… - … advances in chronic …, 2022 - journals.sagepub.com
Background: The pathophysiology of idiopathic intracranial hypertension (IIH), a condition
characterized by raised intracranial pressure, is not well understood. Objectives: We …

Depression and generalized anxiety symptoms in idiopathic intracranial hypertension: prevalence, under-reporting and effect on visual outcome

L Donaldson, V Dezard, M Chen, E Margolin - Journal of the Neurological …, 2022 - Elsevier
Background Patients with idiopathic intracranial hypertension (IIH) have been reported to
have high prevalence of co-existent mood disorders. We investigated the frequency of …

Current and emerging diagnostic and management approaches for idiopathic intracranial hypertension

R Piccus, M Thaller, AJ Sinclair… - Expert Review of …, 2023 - Taylor & Francis
Introduction Idiopathic intracranial hypertension is characterized by raised intracranial
pressure that triggers disabling headaches and can cause permanent visual loss. There is …

Acetazolamide and topiramate lower intracranial pressure through differential mechanisms: The effect of acute and chronic administration

CSJ Westgate, C Kamp‐Jensen… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Diseases of raised intracranial pressure (ICP) cause
severe morbidity and mortality. Multiple drugs are utilised to lower ICP including …

The role of arachnoid granulations and the glymphatic system in the pathophysiology of idiopathic intracranial hypertension

V Mondejar, A Patsalides - Current Neurology and Neuroscience Reports, 2020 - Springer
Abstract Purpose of Review Idiopathic intracranial hypertension (IIH) is a disorder
characterized by long-standing elevated intracranial pressure (ICP). As the name applies …

The Pressure of Headache at the United Kingdom CSF Disorders Day 2023

G Berman, SP Mollan - Neuro-Ophthalmology, 2024 - Taylor & Francis
Headache in intracranial disorders drives significant disability in our patients. Management
principles for secondary headaches require a multidisciplinary approach with expertise from …