Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

Neurodegenerative disorders like Parkinson's disease, Alzheimer's disease, or amyotrophic
lateral sclerosis are affecting a rapidly increasing population worldwide. While common …

The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell
morphology, with a role in several essential cellular processes, including cell migration and …

Traumatic brain injury triggers neuroinflammation that may contribute to progressive
neurodegeneration. We investigated patterns of recruitment of astrocytes and microglia to …

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. TBIs, which
range in severity from mild to severe, occur when a traumatic event, such as a fall, a traffic …

Background Microglia can be activated as proinflammatory (M1) phenotypes and anti-
inflammatory (M2) phenotypes after stroke. Parthenolide (PTL) has anti-inflammatory and …

Growth-associated protein 43 (GAP43), a protein kinase C (PKC)-activated phosphoprotein,
is often implicated in axonal plasticity and regeneration. In this study, we found that GAP43 …

Neurons depend on mitochondrial functions for membrane excitability, neurotransmission,
and plasticity. Mitochondrial dynamics are important for neural cell maintenance. To …

Disease progression in amyotrophic lateral sclerosis (ALS) is characterized by degeneration
of motoneurons (MN) and their axons, but is also influenced by neighboring cells such as …

Objective Rho‐associated kinase (ROCK) is a key regulator of numerous processes in
multiple cell types relevant in stroke pathophysiology. ROCK inhibitors have improved …