The multifaceted role of autophagy in cancer

RC Russell, KL Guan - The EMBO journal, 2022 - embopress.org
Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular
homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic …

Mechanism and medical implications of mammalian autophagy

I Dikic, Z Elazar - Nature reviews Molecular cell biology, 2018 - nature.com
Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy

HT Chen, H Liu, MJ Mao, Y Tan, XQ Mo, XJ Meng… - Molecular cancer, 2019 - Springer
Autophagy is a highly conserved catabolic process that mediates degradation of pernicious
or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and …

[HTML][HTML] Broad targeting of resistance to apoptosis in cancer

RM Mohammad, I Muqbil, L Lowe, C Yedjou… - Seminars in cancer …, 2015 - Elsevier
Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

[HTML][HTML] Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

L Poillet-Perez, G Despouy, R Delage-Mourroux… - Redox biology, 2015 - Elsevier
Cancer formation is a complex and highly regulated multi-step process which is highly
dependent of its environment, from the tissue to the patient. This complexity implies the …

Impact of context-dependent autophagy states on tumor progression

M Assi, AC Kimmelman - Nature cancer, 2023 - nature.com
Macroautophagy is a cellular quality-control process that degrades proteins, protein
aggregates and damaged organelles. Autophagy plays a fundamental role in cancer where …

[HTML][HTML] Autophagy induction impairs migration and invasion by reversing EMT in glioblastoma cells

M Catalano, G D'Alessandro, F Lepore, M Corazzari… - Molecular …, 2015 - Elsevier
Cell migration and invasion are highly regulated processes involved in both physiological
and pathological conditions. Here we show that autophagy modulation regulates the …

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

JM Backer - Biochemical Journal, 2016 - portlandpress.com
The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important
roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient …

Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: a clinical and in vitro investigation

Y Zhao, Q Guo, J Chen, J Hu, S Wang… - Oncology …, 2014 - spandidos-publications.com
Long non-coding RNAs (lncRNAs) are emerging as key molecules in human cancer. Highly
upregulated in liver cancer (HULC), an lncRNA, has recently been revealed to be involved …