Regulation of peptidoglycan synthesis and remodelling

AJF Egan, J Errington, W Vollmer - Nature Reviews Microbiology, 2020 - nature.com
Bacteria surround their cell membrane with a net-like peptidoglycan layer, called sacculus,
to protect the cell from bursting and maintain its cell shape. Sacculus growth during …

Intracellular pathogens: host immunity and microbial persistence strategies

A Thakur, H Mikkelsen… - Journal of immunology …, 2019 - Wiley Online Library
Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

A Taguchi, MA Welsh, LS Marmont, W Lee… - Nature …, 2019 - nature.com
The peptidoglycan cell wall is essential for the survival and morphogenesis of bacteria. For
decades, it was thought that only class A penicillin-binding proteins (PBPs) and related …

Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle

J Salje - Nature Reviews Microbiology, 2021 - nature.com
The Rickettsiales are a group of obligate intracellular vector-borne Gram-negative bacteria
that include many organisms of clinical and agricultural importance, including Anaplasma …

Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen

A Maitra, T Munshi, J Healy, LT Martin… - FEMS microbiology …, 2019 - academic.oup.com
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …

Evaluation of antibiotic resistance mechanisms in gram-negative bacteria

A Gauba, KM Rahman - Antibiotics, 2023 - mdpi.com
Multidrug-resistant Gram-negative bacterial infections are exponentially increasing, posing
one of the most urgent global healthcare and economic threats. Due to the lack of new …

Bacteria-based bioactive materials for cancer imaging and therapy

Y Chen, ZH Li, X Zeng, XZ Zhang - Advanced Drug Delivery Reviews, 2023 - Elsevier
Owing to the unique biological functions, bacteria as biological materials have been widely
used in biomedical field. With advances in biotechnology and nanotechnology, various …

Structural coordination of polymerization and crosslinking by a SEDS–bPBP peptidoglycan synthase complex

M Sjodt, PDA Rohs, MSA Gilman, SC Erlandson… - Nature …, 2020 - nature.com
The shape, elongation, division and sporulation (SEDS) proteins are a highly conserved
family of transmembrane glycosyltransferases that work in concert with class B penicillin …

Wolbachia host shifts: routes, mechanisms, constraints and evolutionary consequences

E Sanaei, S Charlat, J Engelstädter - Biological Reviews, 2021 - Wiley Online Library
Wolbachia is one of the most abundant endosymbionts on earth, with a wide distribution
especially in arthropods. Effective maternal transmission and the induction of various …

Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis

M Sjodt, K Brock, G Dobihal, PDA Rohs, AG Green… - Nature, 2018 - nature.com
The shape, elongation, division and sporulation (SEDS) proteins are a large family of
ubiquitous and essential transmembrane enzymes with critical roles in bacterial cell wall …