Glioblastoma multiforme (GBM) is amongst the deadliest of human cancers, with a median
survival rate of just over one year following diagnosis. Characterized by rapid proliferation …

Calcium ions (Ca2+) play an important role as second messengers in regulating a plethora
of physiological and pathological processes, including the progression of cancer. Several …

Oral cancer causes pain associated with cancer progression. We report here that the
function of the Ca2+ channel ORAI1 is an important regulator of oral cancer pain. ORAI1 …

Approximately one-fourth of patients with essential thrombocythemia or primary
myelofibrosis carry a somatic mutation of the calreticulin gene (CALR), the gene encoding …

The changes in intracellular free calcium (Ca2+) levels are one of the most widely regulators
of cell function; therefore, calcium as a universal intracellular mediator is involved in very …

Advanced prostate cancers that progress to tumor metastases are often considered
incurable or difficult to treat. The etiology of prostate cancers is multi-factorial. Among other …

Breast cancer is one of the most frequent cancer types worldwide and the first cause of
cancer-related deaths in women. Although significant therapeutic advances have been …

Background Among gynecological cancers, ovarian carcinoma has the highest mortality
rate, and chemoresistance is highly prevalent in this cancer. Therefore, novel strategies are …

In recent decades, medical research has been primarily focused on the inherited aspect of
cancers, despite the reality that only 5–10% of tumours discovered are derived from genetic …

KCa3. 1 K+ channels reportedly contribute to the proliferation of breast tumor cells and may
serve pro-tumor functions in the microenvironment. The putative interaction of KCa3. 1 with …