Abstract Since the Von Hippel–Lindau (VHL) disease tumour suppressor gene VHL was
identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical …

Abstract The von Hippel–Lindau disease is caused by inactivating germline mutations of the
VHL tumour suppressor gene and is associated with an increased risk of a variety of …

A mild inhibition of mitochondrial respiration extends the life span of many organisms,
including yeast, worms, flies, and mice [1–10], but the underlying mechanism is unknown …

Bone is a highly vascularized tissue, but the function of angiogenesis in bone modeling and
remodeling is still poorly defined, and the molecular mechanisms that regulate angiogenesis …

The survival of metazoan organisms is dependent upon the utilization of O2 as a substrate
for COX (cytochrome c oxidase), which constitutes Complex IV of the mitochondrial …

Adaptation to hypoxia is a critical cellular event both in pathological settings, such as cancer
and ischaemia, and in normal development and differentiation. Oxygen is thought to be not …

The sensing of oxygen levels and maintenance of oxygen homeostasis is crucial for cells.
The hypoxic-sensitive regulation of gene expression allows information about the oxygen …

Mutations in the von Hippel-Lindau (VHL) gene are responsible for VHL disease, congenital
polycythemia, and are found in many sporadic tumor types as well. Reports of VHL …

Abstract von Hippel-Lindau disease, which is characterized by an increased risk of
hemangioblastomas, clear cell renal carcinomas, and pheochromocytomas, is caused by …

Von Hippel-Lindau disease (VHL) is one of the most common inherited neoplasia
syndromes and is characterized by highly vascular tumors of the eyes, brain, and spine, as …