Illuminating dendritic function with computational models

P Poirazi, A Papoutsi - Nature reviews neuroscience, 2020 - nature.com
Dendrites have always fascinated researchers: from the artistic drawings by Ramon y Cajal
to the beautiful recordings of today, neuroscientists have been striving to unravel the …

Breakdown of spatial coding and interneuron synchronization in epileptic mice

T Shuman, D Aharoni, DJ Cai, CR Lee, S Chavlis… - Nature …, 2020 - nature.com
Temporal lobe epilepsy causes severe cognitive deficits, but the circuit mechanisms remain
unknown. Interneuron death and reorganization during epileptogenesis may disrupt the …

Vasoactive intestinal polypeptide-expressing interneurons in the hippocampus support goal-oriented spatial learning

GF Turi, WK Li, S Chavlis, I Pandi, J O'Hare… - Neuron, 2019 - cell.com
Diverse computations in the neocortex are aided by specialized GABAergic interneurons
(INs), which selectively target other INs. However, much less is known about how these …

Synaptic plasticity in dendrites: complications and coping strategies

BW Mel, J Schiller, P Poirazi - Current opinion in neurobiology, 2017 - Elsevier
Highlights•Different neuron types solve different learning/developmental problems.•Different
neuron types exhibit different dendritic and somatic input–output functions.•A diverse set of …

Synchronous rhythmic interaction enhances children's perceived similarity and closeness towards each other

TC Rabinowitch, A Knafo-Noam - PloS one, 2015 - journals.plos.org
Inter-personal synchronization is important for performing many cooperative tasks. Notably,
synchrony has also been shown to have considerable positive social influences, possibly …

Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators

A Tzilivaki, G Kastellakis, P Poirazi - Nature communications, 2019 - nature.com
Interneurons are critical for the proper functioning of neural circuits. While often
morphologically complex, their dendrites have been ignored for decades, treating them as …

Data-driven multiscale model of macaque auditory thalamocortical circuits reproduces in vivo dynamics

S Dura-Bernal, EY Griffith, A Barczak, MN O'Connell… - Cell reports, 2023 - cell.com
We developed a detailed model of macaque auditory thalamocortical circuits, including
primary auditory cortex (A1), medial geniculate body (MGB), and thalamic reticular nucleus …

A computational network dynamical modeling for abnormal oscillation and deep brain stimulation control of obsessive–compulsive disorder

L Yin, F Han, Y Yu, Q Wang - Cognitive Neurodynamics, 2023 - Springer
Obsessive–compulsive disorder (OCD) is associated with multi-nodal abnormalities in brain
networks, characterized by recurrent intrusive thoughts (obsessions) and repetitive …

Dopamine-mediated major depressive disorder in the neural circuit of ventral tegmental area-nucleus accumbens-medial prefrontal cortex: from biological evidence to …

Y Li, B Zhang, X Pan, Y Wang, X Xu… - Frontiers in Cellular …, 2022 - frontiersin.org
Major depressive disorder (MDD) is a serious psychiatric disorder, with an increasing
incidence in recent years. The abnormal dopaminergic pathways of the midbrain cortical …

[HTML][HTML] Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics

S Dura-Bernal, SA Neymotin, BA Suter, J Dacre… - Cell reports, 2023 - cell.com
Understanding cortical function requires studying multiple scales: molecular, cellular, circuit,
and behavioral. We develop a multiscale, biophysically detailed model of mouse primary …