1, 3-Functionalized cyclobutane structural motifs are ubiquitous in natural products and
pharmaceuticals. Photoinduced alkylation of bicyclo [1.1. 0] butanes (BCBs) offers a step …

Monoacylglycerol lipase (MAGL) regulates endocannabinoid 2-arachidonoylglycerol (2-AG)
and eicosanoid signalling. MAGL inhibition provides therapeutic opportunities but clinical …

Bicyclo [1.1. 0] butanes, as structurally unique compounds with high strained energy and
diverse chemical properties, are becoming increasingly popular building blocks in organic …

It is hard to overestimate the influence of the endocannabinoid signaling (ECS) system on
central nervous system (CNS) function. In the 40 years since cannabinoids were found to …

Herein, we demonstrate the use of E/Z mixtures of α, α-disubstituted crotylhydrazones to
obtain spirocyclic vinylcyclobutanes in a diastereoselective fashion. We show 24 examples …

Cyclobutane is a strained ring that is widely present in bioactive small molecules and natural
products. Contemporary advancements in the synthesis of cyclobutanes and evaluation of …

Glioblastoma (GBM) is an aggressive brain tumor with extremely limited clinical treatment
options. Because of the blood–brain barrier (BBB), it is difficult for anti-GBM drug candidates …

Monoacylglycerol lipase (MAGL) is the key enzyme for the hydrolysis of endocannabinoid 2-
arachidonoylglycerol (2-AG). The central role of MAGL in the metabolism of 2-AG makes it …

Monoacylglycerol lipase (MAGL) is a key enzyme involved in the metabolism of the
endogenous signaling ligand 2-arachidonoylglycerol, a neuroprotective endocannabinoid …

N-heterospirocycles are interesting structural units found in both natural products and
medicinal compounds but have relatively few reliable methods for their synthesis. Here, we …