The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …

HIV-1 can infect both activated and resting, non-dividing cells, following which the viral
genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs …

Gag, the primary structural protein of HIV-1, is recruited to the plasma membrane for virus
assembly by its matrix (MA) domain. Gag is subsequently cleaved into its component …

Multivesicular bodies (MVBs) are intracellular endosomal organelles characterized by
multiple internal vesicles that are enclosed within a single outer membrane. MVBs were …

Several critical steps in the replication cycle of human immunodeficiency virus type 1 (HIV-1)–
entry, assembly and budding–are complex processes that take place at the plasma …

During the late stage of the viral life cycle, HIV-1 Gag assembles into a spherical immature
capsid, and undergoes budding, release, and maturation. Here we review events involved in …

HIV-1-containing internal compartments are readily detected in images of thin sections from
infected cells using conventional transmission electron microscopy, but the origin …

Human immunodeficiency virus type 1 assembly is a multistep process that occurs at the
plasma membrane (PM). Targeting and binding of Gag to the PM are the first steps in this …

Assembly and release of human immunodeficiency virus type 1 (HIV-1) particles is mediated
by the viral Gag polyprotein precursor. Gag is synthesized in the cytosol and rapidly …

Assembly of HIV-1 particles is initiated by the trafficking of viral Gag polyproteins from the
cytoplasm to the plasma membrane, where they co-localize and bud to form immature …