A growing number of studies are revealing that cells can send and receive information by
controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we …

A fundamental problem in biology is to understand how genetic circuits implement core
cellular functions. Time-lapse microscopy techniques are beginning to provide a direct view …

The Notch signaling pathway comprises multiple ligands that are used in distinct biological
contexts. In principle, different ligands could activate distinct target programs in signal …

Visualization of the transcriptome and the nuclear organization in situ has been challenging
for single-cell analysis. Here, we demonstrate a multiplexed single-molecule in situ method …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Summary Stromal-interaction molecules (STIM1/2) sense endoplasmic reticulum (ER) Ca 2+
depletion and activate Orai channels. However, the choreography of interactions between …

The essential role of ORAI1 channels in receptor-evoked Ca2+ signaling is well understood,
yet little is known about the physiological activation of the ORAI channel trio natively …

Cells must respond sensitively to time-varying inputs in complex signaling environments. To
understand how signaling networks process dynamic inputs into gene expression outputs …

The l-arabinose-responsive AraC and its cognate PBAD promoter underlie one of the most
often used chemically inducible prokaryotic gene expression systems in microbiology and …

Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection.
Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining …