Orally administered probiotics encounter various challenges on their journey through the
mouth, stomach, intestine and colon. The health benefits of probiotics are diminished mainly …

The free radical oxidants such as reactive oxygen species, reactive nitrogen species, and
reactive sulfur species are produced inside cells through various metabolic processes. The …

Protein subcellular localization is tightly controlled and intimately linked to protein function in
health and disease. Capturing the spatial proteome—that is, the localizations of proteins and …

Catalase (CAT) is an extensively studied if somewhat enigmatic enzyme that is at the heart
of eukaryotic antioxidant systems with a canonical role in peroxisomal function. The CAT …

Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

Background: The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins
that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and …

Members of the GroEL/HSP60 protein family have been studied for many years because of
their critical roles as ATP-dependent molecular chaperones, so it might come as a surprise …

Automated annotation of protein function is challenging. As the number of sequenced
genomes rapidly grows, the overwhelming majority of protein products can only be …

CELLO2GO (http://cello. life. nctu. edu. tw/cello2go/) is a publicly available, web-based
system for screening various properties of a targeted protein and its subcellular localization …

Pyruvate kinase isoform M2 (PKM2) is a glycolysis enzyme catalyzing conversion of
phosphoenolpyruvate (PEP) to pyruvate by transferring a phosphate from PEP to ADP. We …