Vitamin C and COVID-19 treatment: A systematic review and meta-analysis of randomized controlled trials

D Rawat, A Roy, S Maitra, A Gulati, P Khanna… - Diabetes & Metabolic …, 2021 - Elsevier
Background and aims Vitamin C has been used as an anti-oxidant in various diseases
including viral illnesses like coronavirus disease (COVID-19). Methods Meta-analysis of …

The emerging role of vitamin C as a treatment for sepsis

MG Kashiouris, M L'Heureux, CA Cable, BJ Fisher… - Nutrients, 2020 - mdpi.com
Sepsis, a life-threatening organ dysfunction due to a dysregulated host response to
infection, is a leading cause of morbidity and mortality worldwide. Decades of research have …

Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children

SL Weiss, MJ Peters, W Alhazzani, MSD Agus… - Intensive care …, 2020 - Springer
Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS …

JD Truwit, RD Hite, PE Morris, C DeWilde, A Priday… - Jama, 2019 - jamanetwork.com
Importance Experimental data suggest that intravenous vitamin C may attenuate
inflammation and vascular injury associated with sepsis and acute respiratory distress …

Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the …

T Fujii, N Luethi, PJ Young, DR Frei, GM Eastwood… - Jama, 2020 - jamanetwork.com
Importance It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective
than hydrocortisone alone in expediting resolution of septic shock. Objective To determine …

Effect of ascorbic acid, corticosteroids, and thiamine on organ injury in septic shock: the ACTS randomized clinical trial

A Moskowitz, DT Huang, PC Hou, J Gong, PB Doshi… - Jama, 2020 - jamanetwork.com
Importance The combination of ascorbic acid, corticosteroids, and thiamine has been
identified as a potential therapy for septic shock. Objective To determine whether the …

Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy

AM Pisoschi, A Pop, F Iordache, L Stanca… - European Journal of …, 2022 - Elsevier
Abstract oxidative stress is caused by an abundant generation of reactive oxygen species,
associated to a diminished capacity of the endogenous systems of the organism to …

Impact of childhood malnutrition on host defense and infection

MK Ibrahim, M Zambruni, CL Melby… - Clinical microbiology …, 2017 - Am Soc Microbiol
The global impact of childhood malnutrition is staggering. The synergism between
malnutrition and infection contributes substantially to childhood morbidity and mortality …

Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis

H Hemilä, E Chalker - Journal of intensive care, 2020 - Springer
Background Our recent meta-analysis indicated that vitamin C may shorten the length of ICU
stay and the duration of mechanical ventilation. Here we analyze modification of the vitamin …

Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study

SY Hwang, SM Ryoo, JE Park, YH Jo, DH Jang… - Intensive Care …, 2020 - Springer
Purpose To evaluate the effects of early combination therapy with intravenous vitamin C and
thiamine on recovery from organ failure in patients with septic shock. Methods The ascorbic …