PDZ domains as drug targets

NR Christensen, J Čalyševa… - Advanced …, 2019 - Wiley Online Library
Protein–protein interactions within protein networks shape the human interactome, which
often is promoted by specialized protein interaction modules, such as the postsynaptic …

Synapse type-dependent expression of calcium-permeable AMPA receptors

T Lalanne, J Oyrer, M Farrant… - Frontiers in synaptic …, 2018 - frontiersin.org
Calcium-permeable (CP) AMPA-type glutamate receptors (AMPARs) are known to mediate
synaptic plasticity in several different interneuron (IN) types. Recent evidence suggests that …

Changes in synaptic AMPA receptor concentration and composition in chronic temporal lobe epilepsy

DL Egbenya, S Hussain, YC Lai, J Xia… - Molecular and Cellular …, 2018 - Elsevier
Excitotoxicity caused by excessive stimulation of glutamate receptors, resulting in
pathologically increased Ca 2+-concentrations, is a decisive factor in neurodegenerative …

Cannabidiol inhibits febrile seizure by modulating AMPA receptor kinetics through its interaction with the N-terminal domain of GluA1/GluA2

Y Yu, Z Yang, B Jin, X Qin, X Zhu, J Sun, L Huo… - Pharmacological …, 2020 - Elsevier
Cannabidiol (CBD) is a major phytocannabinoid in Cannabis sativa. CBD is being
increasingly reported as a clinical treatment for neurological diseases. Febrile seizure is one …

A novel approach for vital visualization and studying of neurons containing Ca2+‐permeable AMPA receptors

SG Gaidin, SA Maiorov, DP Laryushkin… - Journal of …, 2023 - Wiley Online Library
Calcium‐permeable AMPA receptors (CP‐AMPARs) play a pivotal role in brain functioning
in health and disease. They are involved in synaptic plasticity, synaptogenesis, and …

Exploring the role of AMPA receptor auxiliary proteins in synaptic functions and diseases

M Qneibi, S Bdir, M Bdair, SA Aldwaik… - The FEBS …, 2024 - Wiley Online Library
α‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) ionotropic glutamate
receptors (AMPARs) mediate rapid excitatory synaptic transmission in the mammalian brain …

Inhibition of AKT/GSK3β/CREB pathway improves the responsiveness to AMPA receptor antagonists by regulating GRIA1 surface expression in chronic epilepsy rats

JE Kim, DS Lee, H Park, TH Kim, TC Kang - Biomedicines, 2021 - mdpi.com
α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR) has been
reported as one of the targets for treatment of epilepsy. Although maladaptive regulation of …

Synaptic dysfunction in epilepsy

АV Zaitsev, DV Amakhin, AV Dyomina… - Journal of Evolutionary …, 2021 - Springer
Epilepsy is one of the prevalent cerebral diseases, and despite intensive research of this
pathology for many years, modern medicine cannot effectively control seizure manifestations …

Role of elevated thrombospondin-1 in kainic acid-induced status epilepticus

Y Zhang, M Zhang, W Zhu, X Pan, Q Wang, X Gao… - Neuroscience …, 2020 - Springer
Previous studies have suggested that thrombospondin-1 (TSP-1) regulates the transforming
growth factor beta 1 (TGF-β1)/phosphorylated Smad2/3 (pSmad2/3) pathway. Moreover …

Sex‐specific role for prefrontal cortical protein interacting with C kinase 1 in cue‐induced cocaine seeking

MM Wickens, JM Kirkland, MC Knouse… - Addiction …, 2021 - Wiley Online Library
Disruption of prefrontal glutamate receptor interacting protein (GRIP), which anchors GluA2‐
containing AMPA receptors (AMPARs) into the synaptic membrane, potentiates cue‐induced …