Abstract Antibody‒drug conjugates (ADCs), which combine the advantages of monoclonal
antibodies with precise targeting and payloads with efficient killing, show great clinical …

Nitrogen containing heterocycles are of immense research interest because they are often
found as naturally occurring bioactive compounds. The prominence of N-heterocycles …

The biological activity and structural diversity of natural products are unsurpassed by any
available synthetic screening libraries. As such, these privileged scaffolds serve as …

Antibody-drug conjugates (ADCs) represent a promising cancer therapy modality which
specifically delivers highly toxic payloads to cancer cells through antigen-specific …

Anthraquinones are a class of abundant compounds obtained from natural sources, being
common in different organisms, such as bacteria, fungi, plants, and some animals. Plants …

With a number of antibody–drug conjugates (ADCs) approved for clinical use as targeted
cancer therapies and numerous candidates in clinical trials, the field of ADCs is emerging as …

Photoredox catalysis is a rapidly evolving platform for synthetic methods development. The
prominent use of acridinium salts as a sustainable option for photoredox catalysts has driven …

Covering: 1970 to 2020 By definition total synthesis is the art and science of making the
molecules of living Nature in the laboratory, and by extension, their analogues. Although …

Background: The anthracene-9, 10-dione (anthraquinone) derivatives represent an
exceptionally valuable class in anticancer drug development. An outstanding antitumor …

The enediyne family of natural products has had a profound impact on modern chemistry,
biology, and medicine, and yet only 11 enediynes have been structurally characterized to …